PMID- 15120602
OWN - NLM
STAT- MEDLINE
DCOM- 20040712
LR  - 20131121
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 1009
IP  - 1-2
DP  - 2004 May 29
TI  - Prenatal cocaine exposure decreases brain-derived neurotrophic factor proteins in 
      the rat brain.
PG  - 228-33
AB  - The pregnant rats received daily sc injections of cocaine (30 mg/kg) or saline 
      from the gestational day (GD) 7 to GD 20. At 1 week postnatal, all pups were 
      killed and the hippocampus, cortex and striatum were dissected out. Levels of 
      brain-derived neurotrophic factor (BDNF) under the basal condition and 
      depolarization with high potassium (40 mM) were measured. The results showed that 
      hippocampal BDNF levels under basal and depolarization conditions were all 
      significantly lower in the pups prenatally exposed to cocaine than those exposed 
      to saline. There were no significant differences in basal BDNF levels between the 
      cocaine and saline groups in the cortex or striatum. However, the prenatally 
      cocaine-treated pups showed significantly less BDNF release following high 
      potassium depolarization than the saline-treated animals did in both these 
      regions. The results support the suggestion that prenatal cocaine exposure 
      decreases BDNF expression in the offspring.
FAU - Yan, Qing-Shan
AU  - Yan QS
AD  - Department of Biomedical and Therapeutic Sciences, University of Illinois College 
      of Medicine, Peoria, IL 61656, USA. QSY@UIC.EDU
FAU - Zheng, Shi-Zhong
AU  - Zheng SZ
FAU - Yan, Shu-E
AU  - Yan SE
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Anesthetics, Local)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - I5Y540LHVR (Cocaine)
RN  - RWP5GA015D (Potassium)
SB  - IM
MH  - Analysis of Variance
MH  - Anesthetics, Local/pharmacology
MH  - Animals
MH  - Animals, Newborn
MH  - Brain/anatomy & histology/*drug effects/metabolism
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Cocaine/*pharmacology
MH  - Enzyme-Linked Immunosorbent Assay/methods
MH  - Female
MH  - Gene Expression Regulation, Developmental/*drug effects
MH  - Potassium/pharmacology
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2004/05/04 05:00
MHDA- 2004/07/13 05:00
CRDT- 2004/05/04 05:00
PHST- 2004/02/20 00:00 [accepted]
PHST- 2004/05/04 05:00 [pubmed]
PHST- 2004/07/13 05:00 [medline]
PHST- 2004/05/04 05:00 [entrez]
AID - S0006899304003889 [pii]
AID - 10.1016/j.brainres.2004.02.052 [doi]
PST - ppublish
SO  - Brain Res. 2004 May 29;1009(1-2):228-33. doi: 10.1016/j.brainres.2004.02.052.