PMID- 15120703
OWN - NLM
STAT- MEDLINE
DCOM- 20041209
LR  - 20040503
IS  - 1056-8727 (Print)
IS  - 1056-8727 (Linking)
VI  - 18
IP  - 2
DP  - 2004 Mar-Apr
TI  - Endothelial dysfunction in patients with type 2 diabetes and the effects of 
      thiazolidinedione antidiabetic agents.
PG  - 91-102
AB  - Endothelial dysfunction is increasingly recognised as a key event in the 
      pathogenesis of atherosclerosis, which occurs in association with insulin 
      resistance early in the course of type 2 diabetes mellitus (T2DM). 
      Thiazolidinediones (TZDs), such as rosiglitazone, are a class of oral 
      antidiabetic agents that act primarily as insulin sensitisers, reducing insulin 
      resistance with associated improvements in glycemic control. Available data 
      indicate that thiozolidinediones also have beneficial effects on numerous markers 
      of endothelial function and profound antiinflammatory activity, indicative of 
      potential antiatherogenic activity. These effects may be of considerable clinical 
      significance if sustained during long-term therapy, given the morbidity and 
      mortality associated with atherosclerosis in T2DM patients.
FAU - Dandona, Paresh
AU  - Dandona P
AD  - Division of Endocrinology, Diabetes and Metabolism, State University of New York 
      at Buffalo and Kaleida Health, Buffalo, NY 14209, USA. pdandona@kaleidahealth.org
FAU - Aljada, Ahmad
AU  - Aljada A
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Diabetes Complications
JT  - Journal of diabetes and its complications
JID - 9204583
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Thiazolidinediones)
SB  - IM
MH  - Coronary Disease/physiopathology/prevention & control
MH  - Diabetes Mellitus, Type 2/*drug therapy/*physiopathology
MH  - Diabetic Angiopathies/physiopathology/prevention & control
MH  - Endothelium, Vascular/*pathology
MH  - Humans
MH  - Hypoglycemic Agents/*therapeutic use
MH  - Thiazolidinediones/*therapeutic use
RF  - 137
EDAT- 2004/05/04 05:00
MHDA- 2004/12/16 09:00
CRDT- 2004/05/04 05:00
PHST- 2002/07/29 00:00 [received]
PHST- 2002/10/21 00:00 [revised]
PHST- 2002/11/22 00:00 [accepted]
PHST- 2004/05/04 05:00 [pubmed]
PHST- 2004/12/16 09:00 [medline]
PHST- 2004/05/04 05:00 [entrez]
AID - S1056872702002593 [pii]
AID - 10.1016/S1056-8727(02)00259-3 [doi]
PST - ppublish
SO  - J Diabetes Complications. 2004 Mar-Apr;18(2):91-102. doi: 
      10.1016/S1056-8727(02)00259-3.