PMID- 15120910
OWN - NLM
STAT- MEDLINE
DCOM- 20040609
LR  - 20061115
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 151
IP  - 1
DP  - 2004 May
TI  - Genetic and pathologic significance of 1p, 17p, and 18q aneusomy and the ERBB2 
      gene in colorectal cancer and related normal colonic mucosa.
PG  - 52-9
AB  - Among chromosome defects in colon cancer, deletions in 1p, 17p, and 18q have been 
      reported as frequent events. To verify this, we investigated 1p, 17p, and 18q 
      aneusomy in 60 colorectal cancers and their surrounding mucosa by means of 
      fluorescence in situ hybridization (FISH). We also evaluated ERBB2 gene (alias 
      HER-2/neu) amplification in a subset of tumors. The genetic picture in tumors was 
      correlated with chromosomal alterations in normal colonic mucosae, as well with 
      clinicopathologic variables. A population of cells in morphologically normal 
      epithelium possesses genetic aberrations common to those in colon cancer, 
      although in different percentages. No significant difference emerged in terms of 
      fraction of nuclei with 17p monosomy between primary tumors and distal mucosal 
      samples. Of tumor samples aneusomic for the three chromosomes, 58.3% also showed 
      aneusomy in related normal colonic mucosa. In neoplastic samples, significant 
      correlation existed between 1p aneusomy and mucosal component (P<0.007), between 
      17p aneusomy and increased depth of invasion (T3-T4) (P<0.05), and between 18q 
      aneusomy and tumor site (P<0.03). None of the evaluated samples, neoplastic or 
      normal, showed ERBB2 gene amplification.
FAU - Cianciulli, A
AU  - Cianciulli A
AD  - Department of Clinical Pathology, Regina Elena Cancer Institute, IFO Via Elio 
      Chianesi 53, 00144 Rome, Italy. cianciulli@ifo.it
FAU - Cosimelli, M
AU  - Cosimelli M
FAU - Marzano, R
AU  - Marzano R
FAU - Merola, R
AU  - Merola R
FAU - Piperno, G
AU  - Piperno G
FAU - Sperduti, I
AU  - Sperduti I
FAU - de la Iglesia, F
AU  - de la Iglesia F
FAU - Leonardo, G
AU  - Leonardo G
FAU - Graziano, F
AU  - Graziano F
FAU - Mancini, R
AU  - Mancini R
FAU - Guadagni, F
AU  - Guadagni F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Chromosomes, Human, Pair 1
MH  - *Chromosomes, Human, Pair 17
MH  - *Chromosomes, Human, Pair 18
MH  - Colon/*metabolism
MH  - Colorectal Neoplasms/*genetics
MH  - Female
MH  - Gene Amplification
MH  - *Genes, erbB-2
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Intestinal Mucosa/metabolism
MH  - Male
MH  - Middle Aged
EDAT- 2004/05/04 05:00
MHDA- 2004/06/21 10:00
CRDT- 2004/05/04 05:00
PHST- 2003/06/02 00:00 [received]
PHST- 2003/09/08 00:00 [revised]
PHST- 2003/09/15 00:00 [accepted]
PHST- 2004/05/04 05:00 [pubmed]
PHST- 2004/06/21 10:00 [medline]
PHST- 2004/05/04 05:00 [entrez]
AID - S0165460803004187 [pii]
AID - 10.1016/j.cancergencyto.2003.09.013 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2004 May;151(1):52-9. doi: 
      10.1016/j.cancergencyto.2003.09.013.