PMID- 15122136
OWN - NLM
STAT- MEDLINE
DCOM- 20040809
LR  - 20221207
IS  - 1526-3231 (Electronic)
IS  - 0749-8063 (Linking)
VI  - 20
IP  - 5
DP  - 2004 May
TI  - Screening for arthrofibrosis after anterior cruciate ligament reconstruction: 
      analysis of association with human leukocyte antigen.
PG  - 469-73
AB  - PURPOSE: Arthrofibrosis represents a severe complication of trauma and 
      reconstructive joint surgery because of generalized connective tissue 
      proliferation resulting in painful joint stiffness. It often appears 
      stereotypical in terms of its clinical and pathologic features, comprising excess 
      deposition of extracellular matrix proteins such as collagen type I, III, and VI 
      and proliferation of fibroblasts. However, trauma and surgery around joints does 
      not always lead to fibrosis, suggesting a genetic predisposition. For a number of 
      autoimmune diseases, strong associations have been described. The objective of 
      the study was to investigate whether an association of HLA (human leukocyte 
      antigen) with primary arthrofibrosis exists. TYPE OF STUDY: Retrospective cohort 
      study. METHODS: Seventeen patients with primary arthrofibrosis after autologous 
      anterior cruciate ligament (ACL) reconstruction were identified and clinically 
      reviewed. Blood samples were taken, and DNA was isolated by column extraction 
      method. DNA samples were typed for the loci HLA-A, -B, -C, -DRB1, and -DQB1. 
      Results were compared with the frequencies of allelic groups as determined for 
      the caucasoid population. RESULTS: HLA-Cw*07 was significantly less often found 
      in the patient group than in the general population (P =.022). The opposite 
      effect was seen for Cw*08, which was found in 17.6% of the patient group but only 
      in 3.8% of the reference group (P =.045). A significant difference was also seen 
      for DQB1*06, because 23.5% of the patients but 48.6% of the reference group 
      possessed an allelic variant of this group (P =.048). However, according to the 
      relatively small number of patients, a statistical bias cannot be excluded. 
      CONCLUSIONS: A possible link may exist between arthrofibrosis and HLA-Cw*07- and 
      DQB1*06-negative as well as Cw*08-positive individuals. Further investigation is 
      necesessary to confirm or vitiate the possible association. LEVEL OF EVIDENCE: 
      Level IV.
FAU - Skutek, Michael
AU  - Skutek M
AD  - Laboratory of Histology and Cell Biology, Department of Traumasurgery, Hannover 
      Medical School, Hannover, Germany. skutek@aol.com
FAU - Elsner, Holger-A
AU  - Elsner HA
FAU - Slateva, Kalina
AU  - Slateva K
FAU - Mayr, Hermann-O
AU  - Mayr HO
FAU - Weig, Thomas-G
AU  - Weig TG
FAU - van Griensven, Martijn
AU  - van Griensven M
FAU - Krettek, Christian
AU  - Krettek C
FAU - Bosch, Ulrich
AU  - Bosch U
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Arthroscopy
JT  - Arthroscopy : the journal of arthroscopic & related surgery : official 
      publication of the Arthroscopy Association of North America and the International 
      Arthroscopy Association
JID - 8506498
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-C Antigens)
RN  - 0 (HLA-C*08 antigen)
RN  - 0 (HLA-C*70 antigen)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
SB  - IM
MH  - Adult
MH  - Anterior Cruciate Ligament/*surgery
MH  - Anterior Cruciate Ligament Injuries
MH  - Connective Tissue/pathology
MH  - Female
MH  - Fibrosis
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Germany
MH  - HLA Antigens/*analysis/genetics
MH  - HLA-C Antigens/analysis/genetics
MH  - HLA-DQ Antigens/analysis/genetics
MH  - HLA-DQ beta-Chains
MH  - Humans
MH  - Joint Diseases/diagnosis/epidemiology/etiology/genetics
MH  - Knee Injuries/rehabilitation
MH  - Knee Joint/pathology
MH  - Male
MH  - Menisci, Tibial/surgery
MH  - Physical Therapy Modalities
MH  - Postoperative Complications/*diagnosis/epidemiology/etiology
MH  - *Plastic Surgery Procedures
MH  - Retrospective Studies
MH  - White People/genetics
EDAT- 2004/05/04 05:00
MHDA- 2004/08/10 05:00
CRDT- 2004/05/04 05:00
PHST- 2004/05/04 05:00 [pubmed]
PHST- 2004/08/10 05:00 [medline]
PHST- 2004/05/04 05:00 [entrez]
AID - S0749806304003068 [pii]
AID - 10.1016/j.arthro.2004.03.003 [doi]
PST - ppublish
SO  - Arthroscopy. 2004 May;20(5):469-73. doi: 10.1016/j.arthro.2004.03.003.