PMID- 15123019
OWN - NLM
STAT- MEDLINE
DCOM- 20040719
LR  - 20131121
IS  - 1525-5050 (Print)
IS  - 1525-5050 (Linking)
VI  - 5
IP  - 2
DP  - 2004 Apr
TI  - Long-term behavioral and morphological consequences of nonconvulsive status 
      epilepticus in rats.
PG  - 180-91
AB  - The aims of the present study were to ascertain whether nonconvulsive status 
      epilepticus (NCSE) could give rise to long-term behavioral deficits and permanent 
      brain damage. Two months after NCSE was elicited with pilocarpine (15 mg/kg i.p.) 
      in LiCl-pretreated adult male rats, animals were assigned to either behavioral 
      (spontaneous behavior, social interaction, elevated plus-maze, rotorod, and 
      bar-holding tests) or EEG studies. Another group of animals was sacrificed and 
      their brains were processed for Nissl and Timm staining as well as for 
      parvalbumin and calbindin immunohistochemistry. Behavioral analysis revealed 
      motor deficits (shorter latencies to fall from rotorod as well as from bar) and 
      disturbances in the social behavior of experimental animals (decreased interest 
      in juvenile conspecific). EEGs showed no apparent abnormalities. Quantification 
      of immunohistochemically stained sections revealed decreased amounts of 
      parvalbumin- and calbindin-immunoreactive neurons in the motor cortex and of 
      parvalbumin-positive neurons in the dentate gyrus. Despite relatively 
      inconspicuous manifestations, NCSE may represent a risk for long-term deficits.
FAU - Krsek, Pavel
AU  - Krsek P
AD  - Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska 
      1083, CZ 142 20 Prague 4, Czech Republic.
FAU - Mikulecka, Anna
AU  - Mikulecka A
FAU - Druga, Rastislav
AU  - Druga R
FAU - Kubova, Hana
AU  - Kubova H
FAU - Hlinak, Zdenek
AU  - Hlinak Z
FAU - Suchomelova, Lucie
AU  - Suchomelova L
FAU - Mares, Pavel
AU  - Mares P
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Epilepsy Behav
JT  - Epilepsy & behavior : E&B
JID - 100892858
RN  - 0 (Calbindins)
RN  - 0 (Convulsants)
RN  - 0 (Parvalbumins)
RN  - 0 (S100 Calcium Binding Protein G)
RN  - 01MI4Q9DI3 (Pilocarpine)
RN  - G4962QA067 (Lithium Chloride)
SB  - IM
MH  - Animals
MH  - Arousal/physiology
MH  - Behavior, Animal/*physiology
MH  - Brain/drug effects/pathology/physiopathology
MH  - Brain Damage, Chronic/chemically induced/pathology/*physiopathology
MH  - Brain Mapping
MH  - Calbindins
MH  - Convulsants
MH  - *Electroencephalography
MH  - Limbic System/pathology/physiopathology
MH  - Lithium Chloride
MH  - Male
MH  - Maze Learning/physiology
MH  - Motor Activity/physiology
MH  - Motor Skills/physiology
MH  - Neocortex/pathology/physiopathology
MH  - Parvalbumins/analysis
MH  - Pilocarpine
MH  - Postural Balance/physiology
MH  - Rats
MH  - Rats, Wistar
MH  - Reaction Time/physiology
MH  - S100 Calcium Binding Protein G/analysis
MH  - Social Behavior
MH  - Status Epilepticus/chemically induced/pathology/*physiopathology
MH  - Video Recording
EDAT- 2004/05/05 05:00
MHDA- 2004/07/20 05:00
CRDT- 2004/05/05 05:00
PHST- 2003/07/23 00:00 [received]
PHST- 2003/11/24 00:00 [revised]
PHST- 2003/11/25 00:00 [accepted]
PHST- 2004/05/05 05:00 [pubmed]
PHST- 2004/07/20 05:00 [medline]
PHST- 2004/05/05 05:00 [entrez]
AID - S1525505003003913 [pii]
AID - 10.1016/j.yebeh.2003.11.032 [doi]
PST - ppublish
SO  - Epilepsy Behav. 2004 Apr;5(2):180-91. doi: 10.1016/j.yebeh.2003.11.032.