PMID- 15123068
OWN - NLM
STAT- MEDLINE
DCOM- 20040810
LR  - 20061115
IS  - 1521-6918 (Print)
IS  - 1521-6918 (Linking)
VI  - 18
IP  - 2
DP  - 2004 Apr
TI  - Microbial-gut interactions in health and disease. Interactions between dendritic 
      cells and bacteria in the regulation of intestinal immunity.
PG  - 255-70
AB  - Dendritic cells (DCs) are immunoregulatory antigen-presenting cells. DCs can be 
      potent activators of naive T cells and influence the generation and homing of 
      effector lymphocytes; they can also induce regulatory mechanisms and maintain 
      non-responsiveness. In part, these different outcomes are influenced by exposure 
      of the DC to microbial products. The regulatory role of DCs is of particular 
      importance at mucosal surfaces such as the intestine, where the immune system 
      exists in intimate association with the external antigenic environment. Much of 
      what we know about DCs has come from studies on the cells outside the 
      gastrointestinal tract but information about gut DCs and their contribution to 
      the specialized immune environment of the gut is now emerging. Here, we review 
      current knowledge on gut DCs, suggest models for interactions between DCs and the 
      commensal microflora in health and disease, and discuss gut DCs as targets for 
      probiotic therapies.
FAU - Stagg, Andrew J
AU  - Stagg AJ
AD  - Antigen Presentation Research Group, Faculty of Medicine, Imperial College, 
      Northwick Park Campus, Watford Road, Harrow HA1 3UJ, Middlesex, UK. 
      a.stag@imperial.ac.uk
FAU - Hart, Ailsa L
AU  - Hart AL
FAU - Knight, Stella C
AU  - Knight SC
FAU - Kamm, Michael A
AU  - Kamm MA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Netherlands
TA  - Best Pract Res Clin Gastroenterol
JT  - Best practice & research. Clinical gastroenterology
JID - 101120605
SB  - IM
MH  - Dendritic Cells/*immunology/physiology
MH  - Enterobacteriaceae/*immunology
MH  - Humans
MH  - Inflammatory Bowel Diseases/*immunology/therapy
MH  - Probiotics/therapeutic use
RF  - 83
EDAT- 2004/05/05 05:00
MHDA- 2004/08/11 05:00
CRDT- 2004/05/05 05:00
PHST- 2004/05/05 05:00 [pubmed]
PHST- 2004/08/11 05:00 [medline]
PHST- 2004/05/05 05:00 [entrez]
AID - S152169180300129X [pii]
AID - 10.1016/j.bpg.2003.10.004 [doi]
PST - ppublish
SO  - Best Pract Res Clin Gastroenterol. 2004 Apr;18(2):255-70. doi: 
      10.1016/j.bpg.2003.10.004.