PMID- 15124942
OWN - NLM
STAT- MEDLINE
DCOM- 20040519
LR  - 20190911
IS  - 0300-9742 (Print)
IS  - 0300-9742 (Linking)
VI  - 33
IP  - 1
DP  - 2004
TI  - Possible importance of immunoglobulin E in foetal loss by mothers with anti-SSA 
      antibody.
PG  - 44-6
AB  - OBJECTIVE: The incidence of foetal loss and/or adverse foetal outcomes, including 
      congenital heart block (CHB), has been investigated in mothers with anti-SSA 
      antibody detected by immunodiffusion or counter-immunoelectrophoresis methods. We 
      investigated the relationship between several serum parameters (such as 
      autoantibodies and immunoglobulins) and foetal loss in patients with anti-SSA 
      antibody, measured by enzyme-linked immunosorbent assay (ELISA). MATERIAL AND 
      METHODS: Thirty-seven women who showed positivity for anti-SSA antibody and had a 
      history of pregnancy were included in this study. Immunoglobulins and several 
      autoantibodies were assayed by routine laboratory methods at our hospital. 
      RESULTS: Our data indicated that immunoglobulin E (IgE) levels were significantly 
      higher in the anti-SSA antibody positive women with foetal loss than in those 
      without, and that a strong positive correlation between IgE and anti-SSA antibody 
      levels was observed in the former group, but not in the latter. CONCLUSION: The 
      serum IgE level seems to be an important factor in the occurrence of foetal loss 
      in mothers with anti-SSA antibody detected by ELISA.
FAU - Sekigawa, I
AU  - Sekigawa I
AD  - Department of Medicine, Juntendo University, Izu-Nagaoka Hospital, Shizuoka, 
      Japan. isekigawa@mva.biglobe.ne.jp
FAU - Seta, N
AU  - Seta N
FAU - Yamada, M
AU  - Yamada M
FAU - Iida, N
AU  - Iida N
FAU - Hashimoto, H
AU  - Hashimoto H
FAU - Ogawa, H
AU  - Ogawa H
LA  - eng
PT  - Journal Article
PL  - England
TA  - Scand J Rheumatol
JT  - Scandinavian journal of rheumatology
JID - 0321213
RN  - 0 (Antibodies, Antinuclear)
RN  - 0 (Autoantibodies)
RN  - 0 (SS-A antibodies)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Antibodies, Antinuclear/*immunology
MH  - Autoantibodies/analysis/*immunology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Fetal Blood/immunology
MH  - Fetal Death/epidemiology/*immunology
MH  - Heart Block/*congenital/immunology
MH  - Humans
MH  - Immunoglobulin E/*immunology
MH  - Maternal Age
MH  - *Maternal-Fetal Exchange
MH  - Pregnancy
MH  - Pregnancy Complications, Cardiovascular/blood/*immunology
MH  - Pregnancy Outcome
MH  - Pregnancy, High-Risk
MH  - Prevalence
MH  - Probability
EDAT- 2004/05/06 05:00
MHDA- 2004/05/20 05:00
CRDT- 2004/05/06 05:00
PHST- 2004/05/06 05:00 [pubmed]
PHST- 2004/05/20 05:00 [medline]
PHST- 2004/05/06 05:00 [entrez]
AID - 10.1080/03009740310004658 [doi]
PST - ppublish
SO  - Scand J Rheumatol. 2004;33(1):44-6. doi: 10.1080/03009740310004658.