PMID- 15125142 OWN - NLM STAT- MEDLINE DCOM- 20040720 LR - 20191210 IS - 0140-0118 (Print) IS - 0140-0118 (Linking) VI - 42 IP - 2 DP - 2004 Mar TI - Ventricular surface activation time imaging from electrocardiogram mapping data. PG - 146-50 AB - Non-invasive imaging of cardiac electrophysiology provides a non-invasive way of obtaining information about electrical excitation. An iterative algorithm based on a general regularisation scheme for non-linear, ill-posed problems in Hilbert scales was applied to the electrocardiographic inverse problem, imaging the ventricular surface activation time (AT) map. This method was applied to electrocardiographic data from a 31-year-old healthy volunteer and a 24-year-old patient suffering from a Wolff-Parkinson-White (WPW) syndrome. The objective was to evaluate non-invasive AT imaging of an autonomous sinus rhythm and to quantify the localisation error of non-invasive AT imaging by localising the accessory pathway of the WPW syndrome and a pacing site for left ventricle pacing. The distances between the invasive and non-invasive localisation of the pacing site and the accessory pathway were 8 mm and 5 mm. The clinical case presented, shows that this non-invasive AT imaging approach may enable the reconstruction of single focal events with sufficient accuracy for potential clinical application. FAU - Modre, R AU - Modre R AD - Institute for Medical Signal Processing & Imaging, University for Health Informatics & Technology Tyrol, Innsbruck, Austria. robert.modre@umit.at FAU - Tilg, B AU - Tilg B FAU - Fischer, G AU - Fischer G FAU - Hanser, F AU - Hanser F FAU - Messnarz, B AU - Messnarz B FAU - Seger, M AU - Seger M FAU - Hintringer, F AU - Hintringer F FAU - Roithinger, F X AU - Roithinger FX LA - eng PT - Evaluation Study PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - Med Biol Eng Comput JT - Medical & biological engineering & computing JID - 7704869 SB - IM MH - Adult MH - Algorithms MH - Body Surface Potential Mapping/*methods MH - Humans MH - Magnetic Resonance Imaging MH - Male MH - Signal Processing, Computer-Assisted MH - Wolff-Parkinson-White Syndrome/*diagnosis EDAT- 2004/05/06 05:00 MHDA- 2004/07/21 05:00 CRDT- 2004/05/06 05:00 PHST- 2004/05/06 05:00 [pubmed] PHST- 2004/07/21 05:00 [medline] PHST- 2004/05/06 05:00 [entrez] AID - 10.1007/BF02344624 [doi] PST - ppublish SO - Med Biol Eng Comput. 2004 Mar;42(2):146-50. doi: 10.1007/BF02344624.