PMID- 15125497
OWN - NLM
STAT- MEDLINE
DCOM- 20040610
LR  - 20190723
IS  - 0011-9059 (Print)
IS  - 0011-9059 (Linking)
VI  - 43
IP  - 2
DP  - 2004 Feb
TI  - Lupus erythematosus induced by medications, ultraviolet radiation, and other 
      exogenous agents: a review, with special focus on the development of subacute 
      cutaneous lupus erythematosus in a genetically predisposed individual.
PG  - 87-94
AB  - Exogenous agents implicated in or suspected of precipitating subacute cutaneous 
      lupus erythematosus (SCLE) and lupus erythematosus (LE) are reviewed. An 
      illustrative case of environmentally induced SCLE is presented. A previously 
      healthy 30-year male homozygous for the tumor necrosis factor-alpha (TNF-alpha) 
      308. A promoter allele developed SCLE after spending several hours removing 
      fertilizer- and pesticide-containing hay from an agricultural barn in the 
      springtime. The cutaneous eruption soon resolved, only to reappear 3 weeks later 
      on the day the patient re-entered the barn. An environmental agent present in the 
      barn, coupled with springtime ultraviolet light, likely triggered the disease in 
      this immunogenetically susceptible individual.
FAU - Shapiro, Michael
AU  - Shapiro M
AD  - Department of Dermatology, University of Pennsylvania Health System, Philadelphia 
      V.A. Hospital, Philadelphia, PA 19104, USA.
FAU - Sosis, Arthur C
AU  - Sosis AC
FAU - Junkins-Hopkins, Jacqueline M
AU  - Junkins-Hopkins JM
FAU - Werth, Victoria P
AU  - Werth VP
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
PL  - England
TA  - Int J Dermatol
JT  - International journal of dermatology
JID - 0243704
RN  - 0 (Insecticides)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adult
MH  - Biopsy, Needle
MH  - Drug-Related Side Effects and Adverse Reactions
MH  - Environmental Exposure/*adverse effects
MH  - Follow-Up Studies
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - Immunohistochemistry
MH  - Insecticides/*adverse effects
MH  - Lupus Erythematosus, Cutaneous/*chemically induced/*genetics/pathology
MH  - Male
MH  - Risk Assessment
MH  - Severity of Illness Index
MH  - Tumor Necrosis Factor-alpha/genetics
MH  - Ultraviolet Rays/adverse effects
RF  - 96
EDAT- 2004/05/06 05:00
MHDA- 2004/06/21 10:00
CRDT- 2004/05/06 05:00
PHST- 2004/05/06 05:00 [pubmed]
PHST- 2004/06/21 10:00 [medline]
PHST- 2004/05/06 05:00 [entrez]
AID - 10.1111/j.1365-4632.2004.02013.x [doi]
PST - ppublish
SO  - Int J Dermatol. 2004 Feb;43(2):87-94. doi: 10.1111/j.1365-4632.2004.02013.x.