PMID- 15127334
OWN - NLM
STAT- MEDLINE
DCOM- 20040520
LR  - 20061115
IS  - 1537-6591 (Electronic)
IS  - 1058-4838 (Linking)
VI  - 38
IP  - 9
DP  - 2004 May 1
TI  - Fusarium infection in hematopoietic stem cell transplant recipients.
PG  - 1237-42
AB  - To characterize the epidemiology and prognostic factors of invasive fusariosis in 
      hematopoietic stem cell transplant (HSCT) recipients, the records of HSCT 
      recipients from 9 hospitals (7 in Brazil and 2 in the United States) were 
      retrospectively reviewed. Sixty-one cases were identified: 54 in allogeneic HSCT 
      recipients and 7 in autologous HSCT recipients. The incidence of fusariosis among 
      allogeneic HSCT recipients varied between a range of 4.21-5.0 cases per 1000 in 
      human leukocyte antigen (HLA)--matched related transplant recipients to 20.19 
      cases per 1000 in HLA-mismatched transplant recipients. The median time period 
      between transplantation and diagnosis of fusariosis was 48 days. Among allogeneic 
      HSCT recipients, a trimodal distribution was observed: a first peak before 
      engraftment, a second peak at a median of 62 days after transplantation, and a 
      third peak >1 year after transplantation. The actuarial survival was 13% (median, 
      13 days). Persistent neutropenia was the single prognostic factor for death 
      identified by multivariate analysis.
FAU - Nucci, Marcio
AU  - Nucci M
AD  - University Hospital, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 
      Brazil. mnucci@hucff.ufrj.br
FAU - Marr, Kieren A
AU  - Marr KA
FAU - Queiroz-Telles, Flavio
AU  - Queiroz-Telles F
FAU - Martins, Carlos A
AU  - Martins CA
FAU - Trabasso, Plinio
AU  - Trabasso P
FAU - Costa, Silvia
AU  - Costa S
FAU - Voltarelli, Julio C
AU  - Voltarelli JC
FAU - Colombo, Arnaldo L
AU  - Colombo AL
FAU - Imhof, Alexander
AU  - Imhof A
FAU - Pasquini, Ricardo
AU  - Pasquini R
FAU - Maiolino, Angelo
AU  - Maiolino A
FAU - Souza, Carmino A
AU  - Souza CA
FAU - Anaissie, Elias
AU  - Anaissie E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20040415
PL  - United States
TA  - Clin Infect Dis
JT  - Clinical infectious diseases : an official publication of the Infectious Diseases 
      Society of America
JID - 9203213
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Brazil/epidemiology
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - *Fusarium
MH  - Hematopoietic Stem Cell Transplantation/*adverse effects
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Mycoses/*epidemiology/etiology/microbiology
MH  - Opportunistic Infections/*epidemiology/etiology
MH  - United States/epidemiology
EDAT- 2004/05/06 05:00
MHDA- 2004/05/21 05:00
CRDT- 2004/05/06 05:00
PHST- 2003/11/05 00:00 [received]
PHST- 2003/12/15 00:00 [accepted]
PHST- 2004/05/06 05:00 [pubmed]
PHST- 2004/05/21 05:00 [medline]
PHST- 2004/05/06 05:00 [entrez]
AID - CID32656 [pii]
AID - 10.1086/383319 [doi]
PST - ppublish
SO  - Clin Infect Dis. 2004 May 1;38(9):1237-42. doi: 10.1086/383319. Epub 2004 Apr 15.