PMID- 15128341
OWN - NLM
STAT- MEDLINE
DCOM- 20040618
LR  - 20071114
IS  - 0002-9270 (Print)
IS  - 0002-9270 (Linking)
VI  - 99
IP  - 5
DP  - 2004 May
TI  - Childhood GERD is a risk factor for GERD in adolescents and young adults.
PG  - 806-12
AB  - OBJECTIVE: The clinical course of gastroesophageal reflux disease (GERD) in 
      children without comorbid illness (neurological deficits, congenital esophageal 
      anomalies, chronic obstructive airway conditions) is unclear. Whether GERD in 
      childhood progresses or predisposes to GERD in adulthood remains unknown. 
      METHODS: We identified a cohort of individuals endoscopically diagnosed with GERD 
      in childhood between 1990 and 1996. We excluded patients with comorbid illnesses. 
      Eligible persons were contacted by telephone in person or through a household 
      member and requested to complete a validated (in adults) symptom questionnaire 
      between February 2001 and February 2003. Respondents were invited to undergo an 
      upper endoscopy or to share results of any endoscopic examination performed 
      within the past 12 months. We calculated the proportion of persons with GERD 
      symptoms (monthly, weekly), and with current use of antisecretory medications 
      (histamine-2-receptor antagonists [H2RA], proton pump inhibitors [PPI]). RESULTS: 
      A total of 207 persons satisfied the inclusion and exclusion criteria and were 
      contacted. Of those, 80 (39%) completed the questionnaire and 14/80 (18%) had an 
      upper endoscopy. The mean age of participants was 20 years (SD = 4, range 10-40); 
      most were Caucasian (73%), and 60% were female. GERD was documented at a mean age 
      of 5 years (approximately a 15-yr duration of follow-up). Most participants 
      (64/80, 80%) had at least monthly heartburn and/or acid regurgitation reported 
      within the past 12 months; 18/80 (23%) reported at least weekly symptoms, and an 
      additional three patients were asymptomatic but taking antisecretory therapy 
      (H2RA or PPI). If all nonresponders were considered free of symptoms, then at 
      least 31% had monthly symptoms, and 9% had weekly symptoms. Overall, 24 (30%) 
      were currently taking either H2RA or PPI, and 19 patients had undergone 
      fundoplication. There were no statistically significant differences between those 
      who reported monthly GERD symptoms, weekly GERD symptoms, or no GERD symptoms as 
      far as demographic features, age of GERD onset, receipt of fundoplication, or 
      current GERD treatment. At endoscopy, three patients had mild to moderate erosive 
      esophagitis. CONCLUSIONS: GERD in otherwise normal children can persist through 
      adolescence and adulthood in a significant proportion of patients who continue to 
      have GERD symptoms and signs, and use antisecretory medications. Childhood GERD 
      is a risk factor for GERD in adolescence and adulthood.
FAU - El-Serag, Hashem B
AU  - El-Serag HB
AD  - Section of Health Services Research, The Houston Veterans Affairs Medical Center, 
      Houston, Texas 77030, USA.
FAU - Gilger, Mark
AU  - Gilger M
FAU - Carter, Junaia
AU  - Carter J
FAU - Genta, Robert M
AU  - Genta RM
FAU - Rabeneck, Linda
AU  - Rabeneck L
LA  - eng
GR  - K24 DK59318/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Gastroenterol
JT  - The American journal of gastroenterology
JID - 0421030
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age of Onset
MH  - Child
MH  - Child, Preschool
MH  - Cohort Studies
MH  - Disease Progression
MH  - Esophagoscopy/methods
MH  - Female
MH  - Follow-Up Studies
MH  - Fundoplication/methods
MH  - Gastroesophageal Reflux/*diagnosis/*epidemiology/surgery
MH  - Humans
MH  - Hydrogen-Ion Concentration
MH  - Infant, Newborn
MH  - Male
MH  - Predictive Value of Tests
MH  - Prevalence
MH  - Probability
MH  - Prospective Studies
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Severity of Illness Index
EDAT- 2004/05/07 05:00
MHDA- 2004/06/24 05:00
CRDT- 2004/05/07 05:00
PHST- 2004/05/07 05:00 [pubmed]
PHST- 2004/06/24 05:00 [medline]
PHST- 2004/05/07 05:00 [entrez]
AID - AJG30098 [pii]
AID - 10.1111/j.1572-0241.2004.30098.x [doi]
PST - ppublish
SO  - Am J Gastroenterol. 2004 May;99(5):806-12. doi: 10.1111/j.1572-0241.2004.30098.x.