PMID- 15129583
OWN - NLM
STAT- MEDLINE
DCOM- 20040524
LR  - 20200422
IS  - 0931-1793 (Print)
IS  - 1439-0450 (Electronic)
IS  - 0931-1793 (Linking)
VI  - 48
IP  - 4
DP  - 2001 May
TI  - Clinical effects of experimental dual infections with porcine reproductive and 
      respiratory syndrome virus followed by swine influenza virus in conventional and 
      colostrum-deprived pigs.
PG  - 283-92
AB  - Previous studies demonstrated that experimental dual infections of pigs with 
      porcine reproductive and respiratory syndrome virus (PRRSV) followed by H1N1 
      influenza virus cause more severe disease and growth retardation than the 
      respective single virus infections. Here three experiments were undertaken to 
      better define the clinical impact of combined PRRSV-H1N1 infections in 
      conventional and caesarean-derived colostrum-deprived (CDCD) pigs. Groups of pigs 
      were inoculated by aerosol with PRRSV followed by H1N1 at 3-, 7- or 14-day 
      intervals. During the post-H1N1 period, mean body temperatures, respiratory signs 
      and mean weight gains in the PRRSV-H1N1 inoculated groups were recorded and 
      compared with those in uninoculated controls (experiments 1 and 2) or in singly 
      virus-inoculated pigs (experiment 3). In a first experiment with conventional 
      pigs, the PRRSV-3d-H1N1 and PRRSV-7d-H1N1 infections induced mean body 
      temperatures > 40.5 degrees C during 8 days (peaks 41.1 and 41.6 degrees C, 
      respectively) and mean growth reductions of 3.4 and 4.8 kg, respectively, during 
      the 2 weeks after H1N1, along with marked depression and respiratory disease. The 
      PRRSV-14d-H1N1 infection, on the contrary, was largely subclinical. In a second 
      experiment with conventional pigs, PRRSV-3d-H1N1 and PRRSV-7d-H1N1 infections 
      were clinically milder, with smaller increases in mean body temperatures (peak 
      40.5 degrees C in both groups) and growth reductions (1.4 and 1.6 kg, 
      respectively). In both groups, only one pig showed prominent general and 
      respiratory signs. In a final experiment with CDCD pigs, PRRSV-7d-H1N1 infection 
      had minimal effects on mean clinical performances and growth and, except for one 
      pig that was severely affected, differences with the single virus inoculations 
      were negligible. Thus, both the time interval between infections and the sanitary 
      status of pigs can affect the clinical outcome of dual PRRSV-H1N1 infections. 
      However, factors so far unknown seem to cause large variations in the clinical 
      response between individual pigs.
FAU - Van Reeth, K
AU  - Van Reeth K
AD  - Laboratory of Virology, Faculty of Veterinary Medicine, Ghent University, 
      Salisburylaan 133, 9820 Merelbeke, Belgium.
FAU - Nauwynck, H
AU  - Nauwynck H
FAU - Pensaert, M
AU  - Pensaert M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - J Vet Med B Infect Dis Vet Public Health
JT  - Journal of veterinary medicine. B, Infectious diseases and veterinary public 
      health
JID - 100955260
SB  - IM
MH  - Animals
MH  - *Influenza A virus
MH  - Orthomyxoviridae Infections/complications/physiopathology/*veterinary
MH  - Porcine Reproductive and Respiratory Syndrome/*physiopathology
MH  - Random Allocation
MH  - Swine/*growth & development
MH  - Swine Diseases/*physiopathology/virology
PMC - PMC7165796
EDAT- 2004/05/08 05:00
MHDA- 2004/05/25 05:00
PMCR- 2020/04/18
CRDT- 2004/05/08 05:00
PHST- 2004/05/08 05:00 [pubmed]
PHST- 2004/05/25 05:00 [medline]
PHST- 2004/05/08 05:00 [entrez]
PHST- 2020/04/18 00:00 [pmc-release]
AID - ZPH438 [pii]
AID - 10.1046/j.1439-0450.2001.00438.x [doi]
PST - ppublish
SO  - J Vet Med B Infect Dis Vet Public Health. 2001 May;48(4):283-92. doi: 
      10.1046/j.1439-0450.2001.00438.x.