PMID- 15131767
OWN - NLM
STAT- MEDLINE
DCOM- 20040708
LR  - 20190725
IS  - 0026-0495 (Print)
IS  - 0026-0495 (Linking)
VI  - 53
IP  - 5
DP  - 2004 May
TI  - Self-monitoring of plasma triglyceride levels to evaluate postprandial response 
      to different nutrients.
PG  - 620-3
AB  - Self-monitoring of plasma triglycerides (TG) may be a very useful tool to 
      monitor, on a daily basis, the TG responses to different nutrients, particularly 
      carbohydrates (CHO) and fat, whose influence on postprandial TG levels is not 
      very well known. Therefore, the aim of the present study was to evaluate the TG 
      response of hypertriglyceridemic patients to a similar amount of calories 
      deriving from different sources of CHO and fat. Thirty-nine hypertriglyceridemic 
      patients were randomly assigned to 1 of 2 experimental groups. In 1 group (the 
      fat group), patients were given a standard meal plus a fat supplement of 300 kcal 
      derived from different types of fat (butter, sunflower margarine, olive oil) for 
      dinner, once a week for 3 weeks. In the other group (the CHO group), patients 
      consumed the same standard meal plus a supplement of 300 kcal derived from 
      different types of CHO (bread, coke, fruit). In both groups, patients measured 
      their plasma TG before and 3 hours after each meal by Accutrend GCT (ROCHE, 
      Mannheim, Germany). A subgroup of patients (n = 18) also performed TG 
      determinations 2 hours after the test meals. The 3-hour TG increments were not 
      significantly different between the different test meals (f = 0.671; P =.52); 
      instead, the TG increments induced by fat supplements were significantly higher 
      than those induced by the CHO supplements (f = 14.31; P =.0001). Similar results 
      were also obtained 2 hours after the test meals. In conclusion, this study shows 
      that the 2- and 3-hour TG responses to fat are higher compared with that induced 
      by carbohydrate. This point, especially if confirmed by experiments with more 
      frequent after meal measurements and of longer duration, should be taken into 
      account in defining the best dietary approach to lower plasma TG levels 
      throughout the whole day.
FAU - Iovine, C
AU  - Iovine C
AD  - Department of Clinical and Experimental Medicine, Federico II University, Naples, 
      Italy.
FAU - Gentile, A
AU  - Gentile A
FAU - Hattemer, A
AU  - Hattemer A
FAU - Pacioni, D
AU  - Pacioni D
FAU - Riccardi, G
AU  - Riccardi G
FAU - Rivellese, A A
AU  - Rivellese AA
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Metabolism
JT  - Metabolism: clinical and experimental
JID - 0375267
RN  - 0 (Cholesterol, HDL)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Dietary Fats)
RN  - 0 (Triglycerides)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Adult
MH  - Cholesterol/blood
MH  - Cholesterol, HDL/blood
MH  - Dietary Carbohydrates/administration & dosage/*pharmacology
MH  - Dietary Fats/administration & dosage/*pharmacology
MH  - Female
MH  - Humans
MH  - Hypertriglyceridemia/metabolism
MH  - Male
MH  - Middle Aged
MH  - Postprandial Period/*physiology
MH  - Time Factors
MH  - Triglycerides/*blood
EDAT- 2004/05/08 05:00
MHDA- 2004/07/09 05:00
CRDT- 2004/05/08 05:00
PHST- 2004/05/08 05:00 [pubmed]
PHST- 2004/07/09 05:00 [medline]
PHST- 2004/05/08 05:00 [entrez]
AID - S0026049504000368 [pii]
AID - 10.1016/j.metabol.2003.12.011 [doi]
PST - ppublish
SO  - Metabolism. 2004 May;53(5):620-3. doi: 10.1016/j.metabol.2003.12.011.