PMID- 15132369
OWN - NLM
STAT- MEDLINE
DCOM- 20040702
LR  - 20190906
IS  - 0022-0736 (Print)
IS  - 0022-0736 (Linking)
VI  - 37
IP  - 1
DP  - 2004 Jan
TI  - Characteristics of new-onset ventricular arrhythmias in pregnancy.
PG  - 47-53
AB  - The characteristics and underlying mechanisms of new-onset ventricular arrhythmia 
      during pregnancy have not been adequately investigated. We studied 11 pregnant 
      women aged 35.4 +/- 3.1 years who experienced new-onset ventricular arrhythmias 
      during pregnancy. The onset of their first episode of ventricular arrhythmia was 
      distributed equally over the 3 trimesters. Ventricular premature contractions 
      (VPCs) and ventricular tachycardia (VT) exhibited a monomorphic configuration in 
      all patients; in 8 (73%) they originated from the right ventricular outflow 
      tract. The frequency of VPCs decreased by more than 95% in 83% of the patients; 
      couplets and VTs disappeared completely in all patients during the postpartum 
      period. All parameters of heart rate variability were significantly lower during 
      pregnancy than postpartum (P < .05). QT and QTc intervals were normal during 
      pregnancy in all patients. The slope and the intersect of the QT/RR relationship 
      obtained from Holter ECGs were not significantly different during pregnancy and 
      in the postpartum period. New-onset ventricular arrhythmias in pregnancy manifest 
      characteristics similar to those of idiopathic VT. Our findings suggest that 
      various hemodynamic and neurohormonal changes associated with pregnancy play an 
      important role in ventricular arrhythmogenesis.
FAU - Nakagawa, Mikiko
AU  - Nakagawa M
AD  - Division of Cardiovascular Science, Department of Laboratory Medicine, Oita 
      Medical University, 1-1 Idaigaoka, Hasama, Oita 879-5593, Japan. 
      mikinak@oita-med.ac.jp
FAU - Katou, Sayo
AU  - Katou S
FAU - Ichinose, Masashi
AU  - Ichinose M
FAU - Nobe, Seiki
AU  - Nobe S
FAU - Yonemochi, Hidetoshi
AU  - Yonemochi H
FAU - Miyakawa, Isao
AU  - Miyakawa I
FAU - Saikawa, Tetsunori
AU  - Saikawa T
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Electrocardiol
JT  - Journal of electrocardiology
JID - 0153605
SB  - IM
MH  - Adult
MH  - Electrocardiography, Ambulatory
MH  - Female
MH  - Heart Rate/physiology
MH  - Humans
MH  - Pilot Projects
MH  - Pregnancy
MH  - Pregnancy Complications, Cardiovascular/*physiopathology
MH  - Retrospective Studies
MH  - Tachycardia, Ventricular/*physiopathology
MH  - Ventricular Premature Complexes/*physiopathology
EDAT- 2004/05/11 05:00
MHDA- 2004/07/03 05:00
CRDT- 2004/05/11 05:00
PHST- 2004/05/11 05:00 [pubmed]
PHST- 2004/07/03 05:00 [medline]
PHST- 2004/05/11 05:00 [entrez]
AID - 10.1016/j.jelectrocard.2003.10.007 [doi]
PST - ppublish
SO  - J Electrocardiol. 2004 Jan;37(1):47-53. doi: 10.1016/j.jelectrocard.2003.10.007.