PMID- 15133176
OWN - NLM
STAT- MEDLINE
DCOM- 20040719
LR  - 20131121
IS  - 0300-9858 (Print)
IS  - 0300-9858 (Linking)
VI  - 41
IP  - 3
DP  - 2004 May
TI  - Immunohistochemical expression of estrogen receptor beta in normal and tumoral 
      canine mammary glands.
PG  - 269-72
AB  - To date, two isoforms of estrogen receptors (ER) have been identified, cloned, 
      and characterized from several species, estrogen receptor-alpha (ERalpha) and 
      estrogen receptor-beta (ERbeta). Although the presence of ERalpha has been 
      demonstrated in normal and tumoral canine mammary tissues, the issue of ERbeta 
      expression has not been addressed in the dog. In this study, we have analyzed the 
      expression of ERbeta in formalin-fixed, paraffin-embedded tissue samples of 
      nonaltered mammary gland, 30 malignant (six complex carcinoma, 12 simple 
      carcinoma, three carcinosarcoma, and nine carcinoma or sarcoma in benign tumor), 
      and five benign (one fibroadenoma, one complex papilloma, one complex adenoma, 
      and two benign mixed tumors) mammary tumors of the dog by using a polyclonal 
      ERbeta antibody and the avidin-biotin-peroxidase complex immunohistochemical 
      technique. Our results show that high numbers of normal ductal and acinar 
      epithelium and approximately one third of canine mammary tumors express ERbeta. 
      This expression was higher in benign than in malignant tumors. Furthermore, 
      expression was higher in complex and mixed histologic subtypes of malignant 
      tumors when compared with simple subtypes.
FAU - Martin de las Mulas, J
AU  - Martin de las Mulas J
AD  - Dpto. de A. y Anatomia Patologica Comparadas, Universidad de Cordoba, Edificio de 
      Sanidad Animal, Campus de Rabanales, Carretera de Madrid-Cadiz, Km. 396, Cordoba 
      14014, Spain. anlmagoj@uco.es.
FAU - Ordas, J
AU  - Ordas J
FAU - Millan, M Y
AU  - Millan MY
FAU - Chacon, F
AU  - Chacon F
FAU - De Lara, M
AU  - De Lara M
FAU - Espinosa de los Monteros, A
AU  - Espinosa de los Monteros A
FAU - Reymundo, C
AU  - Reymundo C
FAU - Jover, A
AU  - Jover A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Vet Pathol
JT  - Veterinary pathology
JID - 0312020
RN  - 0 (Estrogen Receptor beta)
RN  - 0 (Receptors, Estrogen)
RN  - 0 (avidin-horseradish peroxidase complex)
RN  - 1405-69-2 (Avidin)
RN  - 6SO6U10H04 (Biotin)
RN  - EC 1.11.1.- (Horseradish Peroxidase)
SB  - IM
MH  - Animals
MH  - Avidin/*analogs & derivatives
MH  - Biotin
MH  - Dog Diseases/*metabolism/*pathology
MH  - Dogs
MH  - Estrogen Receptor beta
MH  - Female
MH  - *Gene Expression Regulation, Neoplastic
MH  - Horseradish Peroxidase
MH  - Immunohistochemistry
MH  - Mammary Neoplasms, Animal/*metabolism/pathology
MH  - Neoplasms, Glandular and Epithelial/metabolism/pathology/*veterinary
MH  - Ovary/pathology
MH  - Receptors, Estrogen/*metabolism
MH  - Sarcoma/metabolism/pathology/*veterinary
MH  - Uterus/pathology
EDAT- 2004/05/11 05:00
MHDA- 2004/07/20 05:00
CRDT- 2004/05/11 05:00
PHST- 2004/05/11 05:00 [pubmed]
PHST- 2004/07/20 05:00 [medline]
PHST- 2004/05/11 05:00 [entrez]
AID - 41/3/269 [pii]
AID - 10.1354/vp.41-3-269 [doi]
PST - ppublish
SO  - Vet Pathol. 2004 May;41(3):269-72. doi: 10.1354/vp.41-3-269.