PMID- 15134697
OWN - NLM
STAT- MEDLINE
DCOM- 20040630
LR  - 20080910
IS  - 1388-2457 (Print)
IS  - 1388-2457 (Linking)
VI  - 115
IP  - 6
DP  - 2004 Jun
TI  - Handedness is mainly associated with an asymmetry of corticospinal excitability 
      and not of transcallosal inhibition.
PG  - 1305-12
AB  - OBJECTIVE: The study aims to compare transcallosal inhibition (TI), as assessed 
      by the paired-pulse transcranial magnetic stimulation (TMS) technique, in a 
      sample of right-handed subjects (RH) and left-handed subjects (LH). Motor 
      thresholds (MTs) and motor evoked potential (MEP) amplitudes were also measured 
      in the two groups, as an index of corticospinal activity. METHODS: Thirty-two 
      normal subjects (16 RH and 16 LH) were recorded with a paired-pulse TMS paradigm 
      (intensity of both pulses=120% of MT). The inter-stimulus intervals (ISIs) were 
      2, 4, 6, 8, 10, 12, 14, 16, 18, and 20 ms for both motor cortices, and MEP 
      responses were recorded from the abductor digiti minimi muscles. RESULTS: Both 
      groups showed a clear TI centred around the 12 ms ISI, but no difference was 
      found as a function of handedness or of hemisphere. On the other hand, the two 
      groups differed in terms of corticospinal activity, since the hand motor dominant 
      hemisphere had lower MTs than the non-dominant one in LH, and larger MEP 
      amplitudes for the right hand were found in RH. CONCLUSIONS: Results point to a 
      functional asymmetry of the motor cortex on the hand-dominant versus the 
      non-dominant hemisphere, while handedness does not seem associated with 
      functional differences in callosal inhibition, as measured by the 
      inter-hemispheric paired-pulse TMS technique.
FAU - De Gennaro, Luigi
AU  - De Gennaro L
AD  - Dipartimento di Psicologia, Universita di Roma La Sapienza, Via dei Marsi 78, 
      00185 Rome, Italy. luigi.degennaro@uniroma1.it
FAU - Cristiani, Riccardo
AU  - Cristiani R
FAU - Bertini, Mario
AU  - Bertini M
FAU - Curcio, Giuseppe
AU  - Curcio G
FAU - Ferrara, Michele
AU  - Ferrara M
FAU - Fratello, Fabiana
AU  - Fratello F
FAU - Romei, Vincenzo
AU  - Romei V
FAU - Rossini, Paolo M
AU  - Rossini PM
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Netherlands
TA  - Clin Neurophysiol
JT  - Clinical neurophysiology : official journal of the International Federation of 
      Clinical Neurophysiology
JID - 100883319
SB  - IM
MH  - Adult
MH  - Corpus Callosum/*physiology
MH  - Electric Stimulation
MH  - Electromyography
MH  - Evoked Potentials, Motor/*physiology
MH  - Female
MH  - Functional Laterality/*physiology
MH  - Humans
MH  - Magnetics
MH  - Male
MH  - Motor Cortex/physiology
MH  - Muscle, Skeletal/physiology
MH  - Neural Inhibition/*physiology
MH  - Pyramidal Tracts/*physiology
EDAT- 2004/05/12 05:00
MHDA- 2004/07/01 05:00
CRDT- 2004/05/12 05:00
PHST- 2004/01/25 00:00 [accepted]
PHST- 2004/05/12 05:00 [pubmed]
PHST- 2004/07/01 05:00 [medline]
PHST- 2004/05/12 05:00 [entrez]
AID - S1388245704000343 [pii]
AID - 10.1016/j.clinph.2004.01.014 [doi]
PST - ppublish
SO  - Clin Neurophysiol. 2004 Jun;115(6):1305-12. doi: 10.1016/j.clinph.2004.01.014.