PMID- 15135188
OWN - NLM
STAT- MEDLINE
DCOM- 20040909
LR  - 20090825
IS  - 0300-9572 (Print)
IS  - 0300-9572 (Linking)
VI  - 61
IP  - 2
DP  - 2004 May
TI  - Long-term survival and neurological outcome of patients who received recombinant 
      tissue plasminogen activator during out-of-hospital cardiac arrest.
PG  - 123-9
AB  - OBJECTIVE: The long-term outcome in patients who received recombinant tissue 
      plasminogen activator during cardiopulmonary resuscitation (CPR) in 
      out-of-hospital cardiac arrest (OHCA) of non-traumatic aetiology was assessed. 
      METHODS: The neurological outcome in survivors and their level of performance, 
      subjective well-being and quality of life were evaluated. RESULTS: A follow-up 
      study of 27 cardiac arrest survivors was conducted; four patients (15%) died 
      during the first year, a total of seven patients (26%) within 5 years. Twenty-two 
      patients (81%) were discharged from hospital without neurological deficit 
      (cerebral performance category (CPC) score: 1), three patients scored CPC 2 and 
      two patients CPC 3. Heart failure classification on discharge was, according to 
      the New York Heart Association (NYHA) criteria 2.1 +/- 0.9. Fifteen patients 
      (56%) managed to return to their previous level of activity. At the time of 
      follow-up 18 patients (67%) were still alive, of whom 15 responded to a survey 
      regarding life satisfaction. Thirteen patients (87%) judged their situation to be 
      worth living and twelve (80%) considered their survival a second chance, while 
      five (33%) feared they could suffer another cardiac arrest. Reactions from close 
      relatives included fear/anxiety (n = 14; 78%), a sustained burden on family life 
      (n = 12; 67%), and occasional depression (n = 7; 39%). CONCLUSIONS: Thrombolytic 
      therapy during cardiopulmonary resuscitation may produce a favourable 
      neurological outcome. The majority of long-term survivors reported a good 
      subjective quality of life. In one-third of close family members some negative 
      factors had a lasting impact on the quality of daily living.
FAU - Lederer, Wolfgang
AU  - Lederer W
AD  - Division of Disaster and Emergency Medicine, Department of Anaesthesia and 
      Critical Care Medicine, The Leopold Franzens University of Innsbruck, 
      Anichstrasse 35, A-6020 Innsbruck, Austria. wolfgang.lederer@uibk.ac.at
FAU - Lichtenberger, Christa
AU  - Lichtenberger C
FAU - Pechlaner, Christoph
AU  - Pechlaner C
FAU - Kinzl, Johann
AU  - Kinzl J
FAU - Kroesen, Gunnar
AU  - Kroesen G
FAU - Baubin, Michael
AU  - Baubin M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Ireland
TA  - Resuscitation
JT  - Resuscitation
JID - 0332173
RN  - EC 3.4.21.68 (Tissue Plasminogen Activator)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Austria
MH  - Cardiopulmonary Resuscitation/adverse effects/*methods
MH  - Cohort Studies
MH  - Combined Modality Therapy
MH  - Disability Evaluation
MH  - Emergency Medical Services
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Arrest/*mortality/therapy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nervous System Diseases/*epidemiology/etiology
MH  - Probability
MH  - Proportional Hazards Models
MH  - *Quality of Life
MH  - Retrospective Studies
MH  - Survival Analysis
MH  - Survivors
MH  - Time Factors
MH  - Tissue Plasminogen Activator/*therapeutic use
MH  - Treatment Outcome
EDAT- 2004/05/12 05:00
MHDA- 2004/09/10 05:00
CRDT- 2004/05/12 05:00
PHST- 2003/08/07 00:00 [received]
PHST- 2003/11/03 00:00 [revised]
PHST- 2003/12/15 00:00 [accepted]
PHST- 2004/05/12 05:00 [pubmed]
PHST- 2004/09/10 05:00 [medline]
PHST- 2004/05/12 05:00 [entrez]
AID - S0300957203004726 [pii]
AID - 10.1016/j.resuscitation.2003.12.016 [doi]
PST - ppublish
SO  - Resuscitation. 2004 May;61(2):123-9. doi: 10.1016/j.resuscitation.2003.12.016.