PMID- 15135385
OWN - NLM
STAT- MEDLINE
DCOM- 20040924
LR  - 20211203
IS  - 1053-2498 (Print)
IS  - 1053-2498 (Linking)
VI  - 23
IP  - 5
DP  - 2004 May
TI  - Heart transplantation in a patient with multiple sclerosis and 
      mitoxantrone-induced cardiomyopathy.
PG  - 641-3
AB  - We describe a 30-year-old man with end-stage heart failure after therapy with 
      mitoxantrone for multiple sclerosis. A successful orthotopic heart 
      transplantation was performed when intensified medical therapy failed to improve 
      the patient's hemodynamics. In spite of the severe underlying disease he did well 
      on dual immunosuppression with methylprednisone and cyclosporine. Neurologic 
      symptoms remained stable throughout the procedure and, after 2 months, he resumed 
      preoperative ambulatory status. Eight years after the operation, the patient is 
      now in New York Heart Association (NYHA) Class I status. Using canes, he is able 
      to walk short distances. Repeated urinary tract infections caused by Escherichia 
      coli became a problem, but have been controlled by long-term oral antibiotic 
      prophylaxis with trimethoprim.
FAU - Nagele, H
AU  - Nagele H
AD  - Department of Cardiovascular Surgery, University Clinic Eppendorf, Hamburg, 
      Germany. naegele@uke.uni-hamburg.de
FAU - Castel, M A
AU  - Castel MA
FAU - Deutsch, O
AU  - Deutsch O
FAU - Wagner, F M
AU  - Wagner FM
FAU - Reichenspurner, H
AU  - Reichenspurner H
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - J Heart Lung Transplant
JT  - The Journal of heart and lung transplantation : the official publication of the 
      International Society for Heart Transplantation
JID - 9102703
RN  - 0 (Benzimidazoles)
RN  - 0 (methylproamine)
RN  - 83HN0GTJ6D (Cyclosporine)
RN  - BZ114NVM5P (Mitoxantrone)
SB  - IM
MH  - Adult
MH  - Benzimidazoles/administration & dosage
MH  - Cardiomyopathies/*chemically induced/*surgery
MH  - Cyclosporine/administration & dosage
MH  - *Heart Transplantation
MH  - Humans
MH  - Immunosuppression Therapy/methods
MH  - Male
MH  - Mitoxantrone/*adverse effects
MH  - Multiple Sclerosis/*drug therapy
EDAT- 2004/05/12 05:00
MHDA- 2004/09/25 05:00
CRDT- 2004/05/12 05:00
PHST- 2003/02/19 00:00 [received]
PHST- 2003/06/17 00:00 [revised]
PHST- 2003/06/17 00:00 [accepted]
PHST- 2004/05/12 05:00 [pubmed]
PHST- 2004/09/25 05:00 [medline]
PHST- 2004/05/12 05:00 [entrez]
AID - S1053249803003073 [pii]
AID - 10.1016/S1053-2498(03)00307-3 [doi]
PST - ppublish
SO  - J Heart Lung Transplant. 2004 May;23(5):641-3. doi: 
      10.1016/S1053-2498(03)00307-3.