PMID- 15135846
OWN - NLM
STAT- MEDLINE
DCOM- 20040622
LR  - 20220331
IS  - 0895-4356 (Print)
IS  - 0895-4356 (Linking)
VI  - 57
IP  - 4
DP  - 2004 Apr
TI  - A case-control study on adverse effects: H2 blocker or proton pump inhibitor use 
      and risk of vitamin B12 deficiency in older adults.
PG  - 422-8
AB  - OBJECTIVE: Acid-suppressant drugs are commonly prescribed for elderly patients, a 
      population in which vitamin B(12) deficiency is a common disorder. The purpose of 
      this study was to examine the possible association between use of prescription 
      histamine H-2 receptor antagonists (H2RA) or proton pump inhibitors (PPI) and 
      vitamin B(12) deficiency in older adults. STUDY DESIGN AND SETTING: This was a 
      case-control study in a University-based geriatric primary care setting. Among 
      patients aged 65 years or older with documented serum vitamin B(12) studies 
      between 1990 and 1997, 53 vitamin B(12)-deficient cases were compared with 212 
      controls for past or current use of prescription H2RA/PPI according to 
      information in subjects' medical records. RESULTS: Controlling for age, gender, 
      multivitamin use, and Helicobacter pylori infection, chronic (#10878;12 months) 
      current use of H2RA/PPI was associated with a significantly increased risk of 
      vitamin B(12) deficiency (OR 4.45; 95% CI 1.47-13.34). No association was found 
      between past or short-term current use of H2RA/PPI and vitamin B(12) deficiency. 
      CONCLUSION: These findings support an association between chronic use of H2RA/PPI 
      by older adults and development of vitamin B(12) deficiency. Additional studies 
      are needed to confirm these findings.
FAU - Valuck, Robert J
AU  - Valuck RJ
AD  - School of Pharmacy, University of Colorado Health Sciences Center, 4200 E. 9th 
      Ave., C-238, Denver, CO 80262, USA. robert.valuck@uchsc.edu
FAU - Ruscin, J Mark
AU  - Ruscin JM
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Epidemiol
JT  - Journal of clinical epidemiology
JID - 8801383
RN  - 0 (Anti-Ulcer Agents)
RN  - 0 (Histamine H2 Antagonists)
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Anti-Ulcer Agents/administration & dosage/*adverse effects
MH  - Case-Control Studies
MH  - Drug Administration Schedule
MH  - Female
MH  - Histamine H2 Antagonists/administration & dosage/*adverse effects
MH  - Humans
MH  - Male
MH  - Odds Ratio
MH  - *Proton Pump Inhibitors
MH  - Vitamin B 12 Deficiency/*chemically induced
EDAT- 2004/05/12 05:00
MHDA- 2004/06/24 05:00
CRDT- 2004/05/12 05:00
PHST- 2003/08/12 00:00 [accepted]
PHST- 2004/05/12 05:00 [pubmed]
PHST- 2004/06/24 05:00 [medline]
PHST- 2004/05/12 05:00 [entrez]
AID - S0895435603003834 [pii]
AID - 10.1016/j.jclinepi.2003.08.015 [doi]
PST - ppublish
SO  - J Clin Epidemiol. 2004 Apr;57(4):422-8. doi: 10.1016/j.jclinepi.2003.08.015.