PMID- 15135969
OWN - NLM
STAT- MEDLINE
DCOM- 20040719
LR  - 20071114
IS  - 0166-4328 (Print)
IS  - 0166-4328 (Linking)
VI  - 152
IP  - 1
DP  - 2004 Jun 4
TI  - Dissociation of core and shell single-unit activity in the nucleus accumbens in 
      free-choice novelty.
PG  - 59-66
AB  - Core and shell regions of the nucleus accumbens (NAcc) have been implicated in 
      different aspects of goal-directed behavior. To assess these differences at the 
      neuronal level, we evaluated core and shell single-unit activity in eight rats 
      during one-trial, free-choice entry into a novel compartment. Changes in firing 
      rate during approach of (orientation toward) and entry into (nose cross) novelty 
      were assessed relative to a pre-novelty baseline when the animals were 
      behaviorally active. Increases and decreases in neuronal activity were recorded 
      in both regions during both phases of the novelty response. The regional 
      distribution of these responses, however, was significantly different during the 
      approach phase with roughly equal proportions of neuronal excitations (8/29) and 
      inhibitions (6/29) in core but a shift away from excitation (2/40) toward 
      inhibition (12/40) in shell. No regional differences emerged during subsequent 
      approach of the familiar compartment from the novel chamber or during entry to 
      either the novel or familiar compartment. Taken together, our results during 
      approach to free-choice novelty indicate a regional dissociation in NAcc firing 
      rate may play a role in appetitive behavior.
FAU - Wood, David A
AU  - Wood DA
AD  - Program in Neural Science, Department of Psychology, Indiana University, 1101 E. 
      10th St., Bloomington, IN 47405-7007, USA.
FAU - Rebec, George V
AU  - Rebec GV
LA  - eng
GR  - DA 02451/DA/NIDA NIH HHS/United States
GR  - DA 12964/DA/NIDA NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
SB  - IM
MH  - Action Potentials/*physiology
MH  - Animals
MH  - Behavior, Animal
MH  - Choice Behavior/*physiology
MH  - Exploratory Behavior/*physiology
MH  - Male
MH  - Neural Inhibition/physiology
MH  - Nucleus Accumbens/*physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Time Factors
EDAT- 2004/05/12 05:00
MHDA- 2004/07/20 05:00
CRDT- 2004/05/12 05:00
PHST- 2003/02/17 00:00 [received]
PHST- 2003/07/16 00:00 [revised]
PHST- 2003/09/20 00:00 [accepted]
PHST- 2004/05/12 05:00 [pubmed]
PHST- 2004/07/20 05:00 [medline]
PHST- 2004/05/12 05:00 [entrez]
AID - S0166432803003711 [pii]
AID - 10.1016/j.bbr.2003.09.038 [doi]
PST - ppublish
SO  - Behav Brain Res. 2004 Jun 4;152(1):59-66. doi: 10.1016/j.bbr.2003.09.038.