PMID- 15135976
OWN - NLM
STAT- MEDLINE
DCOM- 20040719
LR  - 20171116
IS  - 0166-4328 (Print)
IS  - 0166-4328 (Linking)
VI  - 152
IP  - 1
DP  - 2004 Jun 4
TI  - Effect of estrogen on the lordosis-inhibiting action of ketanserin and SB 206553.
PG  - 129-35
AB  - The effects of the 5-HT(2A/2C) receptor antagonist, ketanserin, and the 5-HT(2C) 
      receptor antagonist, SB 206553, on lordosis behavior were investigated in 
      ovariectomized rats hormonally primed with estradiol benzoate (EB) (0.5 or 25 
      microg) and progesterone (500 microg). Both ketanserin and SB 206553 inhibited 
      lordosis behavior after infusion into the ventromedial nucleus of the 
      hypothalamus (VMN), but ketanserin was slightly more effective than the 5-HT(2C) 
      receptor antagonist. Either drug was more effective in rats primed with 0.5 
      microg EB than in rats hormonally primed with 25 microg EB. These findings 
      support the suggestion that estrogen may enhance functioning of the 5-HT(2) 
      receptor family and thereby protect against the 5-HT(2) receptor antagonists. 
      These data are consistent with prior suggestions that estrogen modulates 
      functioning of 5-HT(2) receptors within the VMN and that 5-HT(2) receptors play a 
      facilitatory role in the modulation of female rat lordosis behavior.
FAU - Sinclair-Worley, L
AU  - Sinclair-Worley L
AD  - Department of Biology, Texas Woman's University, Denton, TX 76204, USA.
FAU - Uphouse, L
AU  - Uphouse L
LA  - eng
GR  - F32 HD 08413/HD/NICHD NIH HHS/United States
GR  - R01 HD 28419/HD/NICHD NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Indoles)
RN  - 0 (Pyridines)
RN  - 0 (Serotonin Antagonists)
RN  - 1S4CJB5ZGN (estradiol 3-benzoate)
RN  - 4G7DS2Q64Y (Progesterone)
RN  - 4TI98Z838E (Estradiol)
RN  - 76330-73-9 (ketanserinol)
RN  - 97F9DE4CT4 (Ketanserin)
RN  - AL4387525T (SB 206553)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Dose-Response Relationship, Drug
MH  - Drug Interactions
MH  - Estradiol/*analogs & derivatives/*pharmacology
MH  - Female
MH  - Hypothalamus, Middle/anatomy & histology/drug effects
MH  - Indoles/*pharmacology
MH  - Ketanserin/*analogs & derivatives/*pharmacology
MH  - Posture
MH  - Progesterone/*pharmacology
MH  - Pyridines/*pharmacology
MH  - Rats
MH  - Rats, Inbred F344
MH  - Serotonin Antagonists/*pharmacology
MH  - Sexual Behavior, Animal/*drug effects
MH  - Time Factors
EDAT- 2004/05/12 05:00
MHDA- 2004/07/20 05:00
CRDT- 2004/05/12 05:00
PHST- 2003/07/18 00:00 [received]
PHST- 2003/09/23 00:00 [revised]
PHST- 2003/09/30 00:00 [accepted]
PHST- 2004/05/12 05:00 [pubmed]
PHST- 2004/07/20 05:00 [medline]
PHST- 2004/05/12 05:00 [entrez]
AID - S0166432803003577 [pii]
AID - 10.1016/j.bbr.2003.09.032 [doi]
PST - ppublish
SO  - Behav Brain Res. 2004 Jun 4;152(1):129-35. doi: 10.1016/j.bbr.2003.09.032.