PMID- 1513626
OWN - NLM
STAT- MEDLINE
DCOM- 19920925
LR  - 20211203
IS  - 0031-403X (Print)
IS  - 0031-403X (Linking)
IP  - 2
DP  - 1992
TI  - [State of hemostasis in hemorrhagic vasculitis in children].
PG  - 16-20
AB  - The purpose of the study was to explore hemostasis in children suffering from 
      hemorrhagic vasculitis (HV) by means of the new amidolytic methods using 
      chromogenic substrates. The patient's plasma was studied for the content of 
      thrombin, trypsin, factor Xa, AT-III, kallikrein, plasmin, free heparin, 
      urokinase, factor 3 of platelets, prothrombin and Willebrand's factor. 69 
      children with HV were entered into the study. All of them were examined during 
      crises. In cutaneous HV, the content of trypsin decreased 3-fold, the content of 
      factor Xa increased 5-fold; there was a negligible increase in the plasmin and 
      AT-III levels; the content of kallikrein rose 2-fold, that of urokinase 60-fold; 
      the release of platelet factor 3 was intensified 1.5-fold, the activity of 
      prothrombin 3-fold. These data indicate that in cutaneous HV, blood coagulation 
      increased. However, the signs of disseminated intravascular coagulation were 
      lacking because of the high blood anticoagulant activity. In mixed HV, the phase 
      of hypercoagulation was not made for by the blood anticoagulant activity, since 
      the latter one was depleted. The capillary toxic nephritis may give rise to 
      disseminated intravascular coagulation associated with the depletion of the 
      anticoagulant component. The gravity of HV and its complications can be predicted 
      according to the characteristics of the anticoagulant component of hemostasis, 
      especially according to the levels of urokinase and AT-III.
FAU - Iakunina, L N
AU  - Iakunina LN
FAU - Plakhuta, T G
AU  - Plakhuta TG
FAU - Tsymbal, I N
AU  - Tsymbal IN
LA  - rus
PT  - Comparative Study
PT  - Journal Article
TT  - Sostoianie gemostaza pri gemorragicheskom vaskulite u detei.
PL  - Russia (Federation)
TA  - Pediatriia
JT  - Pediatriia
JID - 0405563
RN  - 9000-94-6 (Antithrombin III)
RN  - EC 3.4.21.73 (Urokinase-Type Plasminogen Activator)
SB  - IM
MH  - Adolescent
MH  - Antithrombin III/analysis
MH  - Biochemical Phenomena
MH  - Biochemistry
MH  - Blood Coagulation Tests
MH  - Child
MH  - Child, Preschool
MH  - *Hemostasis
MH  - Humans
MH  - IgA Vasculitis/*blood/diagnosis
MH  - Prognosis
MH  - Urokinase-Type Plasminogen Activator/blood
EDAT- 1992/01/01 00:00
MHDA- 1992/01/01 00:01
CRDT- 1992/01/01 00:00
PHST- 1992/01/01 00:00 [pubmed]
PHST- 1992/01/01 00:01 [medline]
PHST- 1992/01/01 00:00 [entrez]
PST - ppublish
SO  - Pediatriia. 1992;(2):16-20.