PMID- 15136936
OWN - NLM
STAT- MEDLINE
DCOM- 20040818
LR  - 20191210
IS  - 0044-2771 (Print)
IS  - 0044-2771 (Linking)
VI  - 42
IP  - 5
DP  - 2004 May
TI  - The magnified endoscopic view of cardia-type mucosa.
PG  - 371-7
AB  - BACKGROUND: The interpretation of magnification endoscopy regarding metaplasia of 
      the esophagogastric junction (EGJ) is still controversial. Histology of areas 
      endoscopically suspected of Barrett's esophagus often reveals only cardia-type 
      mucosa (CTM). The aim of this study was to characterize the surface structure of 
      CTM by magnification endoscopy, in comparison with specialized intestinal 
      metaplasia (SIM) and gastric corpus mucosa. METHODS: Magnification endoscopy was 
      performed in 52 patients with normal EGJ and 36 patients with columnar lined 
      lower esophagus (CLE) on endoscopic examination. Biopsies for histology were 
      obtained from EGJ and CLE segments. In cases with CLE, biopsies were targeted 
      after methylene blue staining. RESULTS: A gyriform or oval pattern was observed 
      in all patients at the normal EGJ, histologically representing CTM. These 
      patterns of CTM were easily discernible from the small pits of corpus mucosa. A 
      gyriform or villous pattern was dominant in CLE, both in areas with CTM and those 
      with SIM. Methylene blue staining was more frequent in SIM than in CTM, but was 
      of insufficient specificity for SIM. CONCLUSIONS: Although magnification 
      endoscopy allows one to differentiate CTM from gastric corpus mucosa, a clear 
      distinction from SIM is not possible. Auxiliary methods that complement 
      magnification endoscopy, like methylene blue staining and acetic acid contrast 
      enhancement, should be evaluated regarding the differentiation between CTM and 
      SIM.
FAU - Peitz, U
AU  - Peitz U
AD  - Department of Gastroenterology, Hepatology, and Infectiology, Otto von Guericke 
      University, Magdeburg, Germany. ulrich.peitz@medizin.uni-magdeburg.de
FAU - Vieth, M
AU  - Vieth M
FAU - Kahl, S
AU  - Kahl S
FAU - Roessner, A
AU  - Roessner A
FAU - Malfertheiner, P
AU  - Malfertheiner P
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Validation Study
PL  - Germany
TA  - Z Gastroenterol
JT  - Zeitschrift fur Gastroenterologie
JID - 0033370
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cardia/*pathology
MH  - Diagnosis, Differential
MH  - Endoscopes, Gastrointestinal
MH  - Endoscopy, Gastrointestinal/*methods
MH  - Esophagogastric Junction/*pathology
MH  - Female
MH  - Gastric Mucosa/*pathology
MH  - Humans
MH  - Image Enhancement/instrumentation/*methods
MH  - Male
MH  - Middle Aged
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
EDAT- 2004/05/12 05:00
MHDA- 2004/08/19 05:00
CRDT- 2004/05/12 05:00
PHST- 2004/05/12 05:00 [pubmed]
PHST- 2004/08/19 05:00 [medline]
PHST- 2004/05/12 05:00 [entrez]
AID - 10.1055/s-2004-812980 [doi]
PST - ppublish
SO  - Z Gastroenterol. 2004 May;42(5):371-7. doi: 10.1055/s-2004-812980.