PMID- 15139566
OWN - NLM
STAT- MEDLINE
DCOM- 20040728
LR  - 20190906
IS  - 0954-6111 (Print)
IS  - 0954-6111 (Linking)
VI  - 98
IP  - 5
DP  - 2004 May
TI  - Treatment of venous thromboembolism with low-molecular-weight heparin: a 
      synthesis of the evidence published in systematic literature reviews.
PG  - 376-86
AB  - OBJECTIVE: To evaluate the methodology and cumulative evidence presented in 
      systematic reviews of clinical trials comparing low-molecular-weight heparin 
      (LMWH) with unfractionated heparin (UFH) for the treatment of venous 
      thromboembolism. METHODS: We reviewed all systematic reviews of clinical trials 
      published until March 2002. Fourteen systematic literature reviews were published 
      between 1994 and 2000. Deficiencies in methodological quality were common, 
      particularly in the description of search strategies, assessment of clinical 
      trial quality, and methods used to combine results. RESULTS: Results of reviews 
      indicate that LMWH is superior to UFH for the treatment of venous 
      thromboembolism, particularly in reducing mortality. Patients with isolated deep 
      venous thrombosis or deep venous thrombosis with concomitant pulmonary embolism 
      seemed to have similar benefit. However, the benefits of LMWH over UFH were 
      smaller in magnitude in reviews that included more recent clinical trials.
FAU - Krishnan, J A
AU  - Krishnan JA
AD  - Division of Pulmonary and Critical Care Medicine, Johns Hopkins School of 
      Medicine, Baltimore, USA. jkrishn2@jhmi.edu
FAU - Segal, J B
AU  - Segal JB
FAU - Streiff, M B
AU  - Streiff MB
FAU - Bolger, D T
AU  - Bolger DT
FAU - Eng, J
AU  - Eng J
FAU - Jenckes, M W
AU  - Jenckes MW
FAU - Tamariz, L J
AU  - Tamariz LJ
FAU - Bass, E B
AU  - Bass EB
LA  - eng
GR  - 290-97-0006/PHS HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - England
TA  - Respir Med
JT  - Respiratory medicine
JID - 8908438
RN  - 0 (Anticoagulants)
RN  - 0 (Heparin, Low-Molecular-Weight)
SB  - IM
MH  - Anticoagulants/*therapeutic use
MH  - Clinical Trials as Topic
MH  - Heparin, Low-Molecular-Weight/*therapeutic use
MH  - Humans
MH  - Pulmonary Embolism/*drug therapy
MH  - Recurrence
MH  - Thromboembolism/*drug therapy
MH  - Treatment Outcome
MH  - Venous Thrombosis/*drug therapy
RF  - 39
EDAT- 2004/05/14 05:00
MHDA- 2004/07/29 05:00
CRDT- 2004/05/14 05:00
PHST- 2004/05/14 05:00 [pubmed]
PHST- 2004/07/29 05:00 [medline]
PHST- 2004/05/14 05:00 [entrez]
AID - S0954-6111(04)00085-X [pii]
AID - 10.1016/j.rmed.2004.02.017 [doi]
PST - ppublish
SO  - Respir Med. 2004 May;98(5):376-86. doi: 10.1016/j.rmed.2004.02.017.