PMID- 15140047 OWN - NLM STAT- MEDLINE DCOM- 20050113 LR - 20111117 IS - 0001-2815 (Print) IS - 0001-2815 (Linking) VI - 63 IP - 6 DP - 2004 Jun TI - Sequencing of two new HLA class II alleles: DRB3*0218 and DQB1*030202. PG - 614-6 AB - Two novel human leukocyte antigen (HLA) class II alleles for DRB3 and DQB1 genes detected in Caucasoid Spanish individuals are described: DRB3*0218 and DQB1*030202. Both alleles have been found during routine high-resolution typing by sequencing. DRB3*0218 shows a novel DRB3 gene polymorphic position, located at amino acid residue 58, alanine to glutamic acid. This residue is shared by several DRB1 alleles, including all described DRB1*11 subtypes. DQB1*030202 differs from DQB1*030201 by a point mutation at position 319 (T to C). This nucleotide change generates a new codon at amino acid position 75 that is not shared by any other DQB1 allele. CI - Copyright 2004 Blackwell Munksgaard FAU - Balas, A AU - Balas A AD - Histocompatibility Department, Regional Transfusion Center of Madrid, Madrid, Spain. abalas.trans@salud.madrid.org FAU - Aviles, M J AU - Aviles MJ FAU - Lillo, R AU - Lillo R FAU - Alonso-Nieto, M AU - Alonso-Nieto M FAU - Zarapuz, L AU - Zarapuz L FAU - Garcia-Villaescusa, R AU - Garcia-Villaescusa R FAU - Garcia-Sanchez, F AU - Garcia-Sanchez F FAU - Vicario, J L AU - Vicario JL LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - England TA - Tissue Antigens JT - Tissue antigens JID - 0331072 RN - 0 (HLA-DQ Antigens) RN - 0 (HLA-DQ beta-Chains) RN - 0 (HLA-DQB1 antigen) RN - 0 (HLA-DR Antigens) RN - 0 (HLA-DRB3 Chains) RN - 0 (HLA-DRB3*02:18 antigen) SB - IM MH - Amino Acid Sequence MH - Base Sequence MH - Exons MH - HLA-DQ Antigens/*genetics MH - HLA-DQ beta-Chains MH - HLA-DR Antigens/*genetics MH - HLA-DRB3 Chains MH - Humans MH - Molecular Sequence Data MH - Sequence Alignment EDAT- 2004/05/14 05:00 MHDA- 2005/01/14 09:00 CRDT- 2004/05/14 05:00 PHST- 2004/05/14 05:00 [pubmed] PHST- 2005/01/14 09:00 [medline] PHST- 2004/05/14 05:00 [entrez] AID - TAN196 [pii] AID - 10.1111/j.0001-2815.2004.00196.x [doi] PST - ppublish SO - Tissue Antigens. 2004 Jun;63(6):614-6. doi: 10.1111/j.0001-2815.2004.00196.x.