PMID- 15140072
OWN - NLM
STAT- MEDLINE
DCOM- 20041124
LR  - 20221207
IS  - 0893-5785 (Print)
IS  - 0893-5785 (Linking)
VI  - 17
IP  - 3
DP  - 2004 Jun
TI  - Difference in pathogenesis between vitiligo vulgaris and halo nevi associated 
      with vitiligo is supported by an HLA association study.
PG  - 270-4
AB  - Human leukocyte antigen (HLA) class II associations with two subtypes of 
      vitiligo: vitiligo vulgaris and halo nevi associated with vitiligo were 
      investigated. In previous studies associations between vitiligo and HLA antigens 
      have been reported but these two subtypes have never been taken into account. 
      However from a clinical and histological point of view, a difference in 
      (auto)-immune pathogenesis can be expected. This difference might be reflected in 
      an association with different HLA alleles. Seventy-six unrelated Dutch 
      Caucasians, 40 with vitiligo vulgaris and 36 with halo nevi associated with 
      vitiligo were included. A panel of randomly chosen HLA typed healthy Dutch blood 
      donors (n = 2400) served as control population. HLA-DR and -DQ typing was carried 
      out on blood samples by amplifying genomic DNA using polymerase chain reaction 
      followed by dot blot hybridization with sequence specific oligonucleotides. The 
      main outcome measures were odds ratio (OR), uncorrected P-value (P(u)) and 
      corrected P-value. There were distinct differences in the clinical manifestations 
      between vitiligo vulgaris and halo nevi associated with vitiligo with respect to 
      precipitating factors, extent and progress of the disease and the association 
      with other auto-immune diseases in the two subtypes and their respective first 
      degree family members. Our stratification reveals differences in HLA class II 
      between both subtypes and between subtypes and controls. A case-control 
      association study showed a significant positive association of HLA-DR4 (OR = 
      2.787, P(u) = 0.0022) and DR53 (OR = 2.249, P(u) = 0.0153) and a negative 
      association of HLA-DR3 (OR = 0.195, P(u) = 0.0024) with vitiligo vulgaris. The 
      group with halo nevi associated with vitiligo did not show these associations, 
      but had a significant negative association with HLA-DR11 (OR = 0.083, P(u) = 
      0.0067). In conclusion, the differences in HLA association within clinical 
      subtypes of vitiligo support our suggestion that vitiligo vulgaris and halo nevi 
      associated with vitiligo have distinct pathogenic mechanisms.
FAU - de Vijlder, Hannah C
AU  - de Vijlder HC
AD  - Netherlands Institute for Pigment Disorders, Department of Dermatology, Academic 
      Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
FAU - Westerhof, Wiete
AU  - Westerhof W
FAU - Schreuder, Geziena M Th
AU  - Schreuder GM
FAU - de Lange, Peter
AU  - de Lange P
FAU - Claas, Frans H J
AU  - Claas FH
LA  - eng
PT  - Journal Article
PL  - Denmark
TA  - Pigment Cell Res
JT  - Pigment cell research
JID - 8800247
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Comorbidity
MH  - Female
MH  - Gene Frequency
MH  - Genes, MHC Class II/genetics
MH  - Histocompatibility Antigens Class II/classification/*genetics
MH  - Histocompatibility Testing
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Netherlands/epidemiology
MH  - Nevus, Pigmented/epidemiology/*genetics/pathology
MH  - Odds Ratio
MH  - Vitiligo/epidemiology/*genetics/pathology
MH  - White People/genetics
EDAT- 2004/05/14 05:00
MHDA- 2004/12/16 09:00
CRDT- 2004/05/14 05:00
PHST- 2004/05/14 05:00 [pubmed]
PHST- 2004/12/16 09:00 [medline]
PHST- 2004/05/14 05:00 [entrez]
AID - PCR145 [pii]
AID - 10.1111/j.1600-0749.2004.00145.x [doi]
PST - ppublish
SO  - Pigment Cell Res. 2004 Jun;17(3):270-4. doi: 10.1111/j.1600-0749.2004.00145.x.