PMID- 15142852
OWN - NLM
STAT- MEDLINE
DCOM- 20040608
LR  - 20200930
IS  - 0363-6119 (Print)
IS  - 0363-6119 (Linking)
VI  - 286
IP  - 6
DP  - 2004 Jun
TI  - Oxygen-dependent and tissue-specific regulation of erythropoietin gene 
      expression.
PG  - R977-88
AB  - Hypoxia-inducible expression of the gene encoding for the glycoprotein hormone 
      erythropoietin (EPO) is the paradigm of oxygen-regulated gene expression. EPO is 
      the main regulator of red blood cell production and more than 100 years of 
      research on the regulation of EPO production have led to the identification of a 
      widespread cellular oxygen sensing mechanism. Central to this signaling cascade 
      is the transcription factor complex hypoxia-inducible factor-1 (HIF-1). 
      Meanwhile, it is known that HIF-1 controls more than 50 oxygen-dependent genes 
      and is now recognized as the main regulator of oxygen homoeostasis in the body. 
      In addition to hypoxic induction, expression of the EPO gene is tightly regulated 
      in a tissue-specific manner. During ontogeny, production of EPO required for 
      erythropoiesis is switched from the fetal liver to the kidneys. Here EPO is 
      mainly synthesized in adulthood. Production of EPO has also been found in organs 
      where it has nonerythropoietic functions: EPO is important for development of the 
      brain and is neuroprotective, whereas it stimulates angiogenesis in the 
      reproductive tract and possibly in other organs. Understanding oxygen and 
      tissue-specific regulation of EPO production is of high relevance for physiology. 
      Moreover, this knowledge might be useful for new therapies to treat human 
      diseases.
FAU - Fandrey, Joachim
AU  - Fandrey J
AD  - Institut fur Physiologie, Universitat Duisburg-Essen, Hufelandstr. 55, D-45147 
      Essen, Germany. joachim.fandrey@uni-essen.de
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Am J Physiol Regul Integr Comp Physiol
JT  - American journal of physiology. Regulatory, integrative and comparative 
      physiology
JID - 100901230
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (HIF1A protein, human)
RN  - 0 (Hypoxia-Inducible Factor 1)
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
RN  - 0 (Nuclear Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Transcription Factors)
RN  - 11096-26-7 (Erythropoietin)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Animals
MH  - DNA-Binding Proteins/physiology
MH  - Erythropoietin/*biosynthesis/genetics
MH  - Gene Expression Regulation/*physiology
MH  - Humans
MH  - Hypoxia-Inducible Factor 1
MH  - Hypoxia-Inducible Factor 1, alpha Subunit
MH  - Molecular Conformation
MH  - Nuclear Proteins/physiology
MH  - Organ Specificity
MH  - Oxygen/*physiology
MH  - RNA, Messenger/biosynthesis
MH  - Regulatory Sequences, Nucleic Acid/genetics
MH  - *Transcription Factors
RF  - 165
EDAT- 2004/05/15 05:00
MHDA- 2004/06/21 10:00
CRDT- 2004/05/15 05:00
PHST- 2004/05/15 05:00 [pubmed]
PHST- 2004/06/21 10:00 [medline]
PHST- 2004/05/15 05:00 [entrez]
AID - 286/6/R977 [pii]
AID - 10.1152/ajpregu.00577.2003 [doi]
PST - ppublish
SO  - Am J Physiol Regul Integr Comp Physiol. 2004 Jun;286(6):R977-88. doi: 
      10.1152/ajpregu.00577.2003.