PMID- 1514498
OWN - NLM
STAT- MEDLINE
DCOM- 19920925
LR  - 20220309
IS  - 0002-8703 (Print)
IS  - 0002-8703 (Linking)
VI  - 124
IP  - 3
DP  - 1992 Sep
TI  - The influence of obesity on left ventricular filling and systolic function.
PG  - 694-9
AB  - Little information on the possible influence of obesity on diastolic function is 
      available. Thus we studied 24 asymptomatic obese volunteers (greater than 120% 
      ideal body weight; mean 153 +/- 30%), aged 34 +/- 11 years. Each obese subject 
      was matched for age, height, and sex, with a healthy normal-weight control 
      subject. Isovolumic relaxation time (IVRT) and diastolic filling indexes were 
      determined by pulsed Doppler echocardiography. The IVRT was significantly 
      prolonged in the obese group (84 +/- 17 msec) as compared with the control group 
      (57 +/- 13 msec; p less than 0.0002). Multiple regression analysis showed that 
      percentage of ideal body weight was the most important predictor of peak early 
      filling velocity (r = 0.59, p less than 0.005) and mean deceleration rate of 
      early filling (r = 0.61, p less than 0.005) in the obese group. However, age as 
      compared with percentage of ideal body weight was a more important determinant of 
      the relative distribution of early and atrial filling, such as peak 
      early-to-atrial filling velocity ratio (r = -0.75, p less than 0.0001). Ejection 
      fraction, heart rate, and blood pressure did not differ between the obese and 
      control groups. In conclusion, obesity is associated with preclinical 
      abnormalities of IVRT, which may reflect impaired relaxation. The IVRT may be 
      useful in the early detection of left ventricular dysfunction in obesity. Last, 
      studies comparing Doppler indexes of diastolic filling among groups must control 
      for potential differences in percentage of ideal body weight.
FAU - Stoddard, M F
AU  - Stoddard MF
AD  - Department of Internal Medicine, University of Louisville, KY 40292.
FAU - Tseuda, K
AU  - Tseuda K
FAU - Thomas, M
AU  - Thomas M
FAU - Dillon, S
AU  - Dillon S
FAU - Kupersmith, J
AU  - Kupersmith J
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am Heart J
JT  - American heart journal
JID - 0370465
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Body Weight
MH  - Diastole
MH  - Echocardiography, Doppler
MH  - Female
MH  - Humans
MH  - Isometric Contraction
MH  - Male
MH  - Middle Aged
MH  - Myocardial Contraction
MH  - Obesity/diagnostic imaging/*physiopathology
MH  - Regression Analysis
MH  - Systole
MH  - Time Factors
MH  - *Ventricular Function, Left
EDAT- 1992/09/01 00:00
MHDA- 1992/09/01 00:01
CRDT- 1992/09/01 00:00
PHST- 1992/09/01 00:00 [pubmed]
PHST- 1992/09/01 00:01 [medline]
PHST- 1992/09/01 00:00 [entrez]
AID - 0002-8703(92)90280-9 [pii]
AID - 10.1016/0002-8703(92)90280-9 [doi]
PST - ppublish
SO  - Am Heart J. 1992 Sep;124(3):694-9. doi: 10.1016/0002-8703(92)90280-9.