PMID- 15145609
OWN - NLM
STAT- MEDLINE
DCOM- 20040818
LR  - 20071114
IS  - 0165-5728 (Print)
IS  - 0165-5728 (Linking)
VI  - 151
IP  - 1-2
DP  - 2004 Jun
TI  - Alterations in chemokine expression following Theiler's virus infection and 
      restraint stress.
PG  - 103-15
AB  - Restraint stress (RS) applied to mice during acute infection with Theiler's virus 
      causes corticosterone-induced immunosuppression. This effect was further 
      investigated by measuring chemokine changes in the spleen and central nervous 
      system (CNS) using an RNase Protection Assay. mRNAs for lymphotactin (Ltn), 
      interferon-induced protein-10 (IP-10), MIP-1 beta, monocyte chemoattractant 
      protein-1 (MCP-1) and TCA-3 were detected in the spleen at day 2 pi, but not in 
      the brain of CBA mice infected with Theiler's virus. Ltn, IP-10 and RANTES were 
      elevated in both the spleen and the brain at day 7 pi, and were significantly 
      decreased by RS in the brain. RS also resulted in decreased inflammation within 
      the CNS.
FAU - Mi, W
AU  - Mi W
AD  - Department of Veterinary Anatomy and Public Health, College of Veterinary 
      Medicine, Texas A&M University, College Station, TX 77843, USA.
FAU - Belyavskyi, M
AU  - Belyavskyi M
FAU - Johnson, R R
AU  - Johnson RR
FAU - Sieve, A N
AU  - Sieve AN
FAU - Storts, R
AU  - Storts R
FAU - Meagher, M W
AU  - Meagher MW
FAU - Welsh, C J R
AU  - Welsh CJ
LA  - eng
GR  - R01 NS39569/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (Chemokines)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Animals
MH  - Brain/*immunology/pathology/virology
MH  - Cardiovirus Infections/*immunology/physiopathology
MH  - Chemokines/*biosynthesis
MH  - Male
MH  - Mice
MH  - RNA, Messenger/analysis
MH  - Restraint, Physical
MH  - Spleen/immunology/pathology/virology
MH  - Stress, Psychological/*immunology
MH  - Theilovirus/*metabolism
MH  - Thymus Gland/immunology/pathology/virology
EDAT- 2004/05/18 05:00
MHDA- 2004/08/19 05:00
CRDT- 2004/05/18 05:00
PHST- 2003/12/08 00:00 [received]
PHST- 2004/02/23 00:00 [revised]
PHST- 2004/02/23 00:00 [accepted]
PHST- 2004/05/18 05:00 [pubmed]
PHST- 2004/08/19 05:00 [medline]
PHST- 2004/05/18 05:00 [entrez]
AID - S0165572804000803 [pii]
AID - 10.1016/j.jneuroim.2004.02.010 [doi]
PST - ppublish
SO  - J Neuroimmunol. 2004 Jun;151(1-2):103-15. doi: 10.1016/j.jneuroim.2004.02.010.