PMID- 15145621
OWN - NLM
STAT- MEDLINE
DCOM- 20040818
LR  - 20220310
VI  - 45
IP  - 2
DP  - 2004 May
TI  - Critical role of brain-derived neurotrophic factor in mood disorders.
PG  - 104-14
AB  - The purpose of this review is to integrate what is currently known about the role 
      of brain-derived neurotrophic factor (BDNF) in the pathophysiology of mood 
      disorders including major depressive disorder (MDD) and bipolar disorder (BD). We 
      reviewed the pre-clinical and clinical papers demonstrating that BDNF plays a 
      role in the pathophysiology of mood disorders and in the mechanism of action of 
      therapeutic agents. Pre-clinical studies suggest that the expression of BDNF 
      might be a downstream target of antidepressant treatments and mood stabilizers 
      such as lithium and valproate, and that BDNF exerts antidepressant activity in 
      animal models of depression. Furthermore, BDNF protects against stress-induced 
      neuronal damage, and it might affect neurogenesis in the hippocampus, which is 
      thought to be involved in the pathogenesis of mood disorders. Clinical studies 
      have demonstrated that serum levels of BDNF in drug-naive patients with MDD are 
      significantly decreased as compared with normal controls, and that BDNF might be 
      an important agent for therapeutic recovery from MDD. Moreover, recent findings 
      from family-based association studies have suggested that the BDNF gene is a 
      potential risk locus for the development of BD. These findings suggest that BDNF 
      plays a critical role in the pathophysiology of mood disorders and in the 
      activity of therapeutic agents in patients with mood disorders. New agents 
      capable of enhancing BDNF levels may lead aid the development of novel 
      therapeutic drugs for patients with mood disorders.
CI  - Copyright 2004 Elsevier B.V.
FAU - Hashimoto, Kenji
AU  - Hashimoto K
AD  - Department of Psychiatry, Chiba University Graduate School of Medicine, 1-8-1 
      Inohana, Chiba 260-8670, Japan. hashimoto@faculty.chiba-u.jp
FAU - Shimizu, Eiji
AU  - Shimizu E
FAU - Iyo, Masaomi
AU  - Iyo M
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - Brain Res Brain Res Rev
JT  - Brain research. Brain research reviews
JID - 8908638
RN  - 0 (Antimanic Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Neuroprotective Agents)
SB  - IM
MH  - Animals
MH  - Antimanic Agents/pharmacology
MH  - Brain/metabolism/*physiopathology
MH  - Brain-Derived Neurotrophic Factor/agonists/*physiology/therapeutic use
MH  - Depressive Disorder, Major/drug therapy/metabolism/physiopathology
MH  - Hippocampus/drug effects/metabolism/pathology
MH  - Humans
MH  - Mood Disorders/drug therapy/metabolism/*physiopathology
MH  - Nerve Degeneration/drug therapy/physiopathology/prevention & control
MH  - Neuroprotective Agents/pharmacology/therapeutic use
RF  - 121
EDAT- 2004/05/18 05:00
MHDA- 2004/08/19 05:00
CRDT- 2004/05/18 05:00
PHST- 2004/02/19 00:00 [accepted]
PHST- 2004/05/18 05:00 [pubmed]
PHST- 2004/08/19 05:00 [medline]
PHST- 2004/05/18 05:00 [entrez]
AID - S0165017304000189 [pii]
AID - 10.1016/j.brainresrev.2004.02.003 [doi]
PST - ppublish
SO  - Brain Res Brain Res Rev. 2004 May;45(2):104-14. doi: 
      10.1016/j.brainresrev.2004.02.003.