PMID- 15145866
OWN - NLM
STAT- MEDLINE
DCOM- 20040615
LR  - 20231103
IS  - 1468-201X (Electronic)
IS  - 1355-6037 (Print)
IS  - 1355-6037 (Linking)
VI  - 90
IP  - 6
DP  - 2004 Jun
TI  - Transcoronary ablation of septal hypertrophy for hypertrophic obstructive 
      cardiomyopathy: feasibility, clinical benefit, and short term results in elderly 
      patients.
PG  - 638-44
AB  - OBJECTIVE: To evaluate symptomatic and haemodynamic results of transcoronary 
      ablation of septal hypertrophy for hypertrophic obstructive cardiomyopathy in 
      elderly patients. SETTING: Tertiary referral centre for patients with 
      hypertrophic obstructive cardiomyopathy. DESIGN: Retrospective study of two 
      groups of consecutive patients divided at a median age (59 years). PATIENTS: 
      Transcoronary ablation of septal hypertrophy was compared for 80 patients (group 
      1) < 60 years of age and 77 patients (group 2) > or = 60 years of age. At 
      baseline both groups were similar concerning the proportion of familial 
      hypertrophic cardiomyopathy, concomitant moderate hypertension, prior syncope, 
      left ventricular outflow obstruction, left ventricular end diastolic pressure, 
      and left ventricular ejection fraction. Patients in group 2 had a lower 
      interventricular septal thickness and more severe disease as measured by New York 
      Heart Association (NYHA) functional class, exercise capacity, pulmonary artery 
      mean pressure at workload, and cardiac index at peak exercise. RESULTS: Median 
      follow up was seven months after transcoronary ablation of septal hypertrophy. 
      Both groups had a significant and similar improvement in basal and provokable 
      obstruction, septal thickness, NYHA functional class, exercise tolerance, peak 
      oxygen consumption, and pulmonary artery mean pressure at workload. Significant 
      differences, compared with the younger group, were a higher proportion of 
      persistent total atrioventricular block (5% v 17%, p = 0.015) and a slight 
      decrease in left ventricular ejection fraction (3 (12) v -6 (11)%, p = 0.001) in 
      the elderly, despite a trend to a lower induced peak creatine kinase activity 
      (596 (339) v 491 (331) U/l, p = 0.051). CONCLUSIONS: Short term results with 
      transcoronary ablation of septal hypertrophy suggest that independent of a 
      patient's age similar treatment strategies are justified in hypertrophic 
      obstructive cardiomyopathy.
FAU - Gietzen, F H
AU  - Gietzen FH
AD  - Department of Cardiology and Internal Intensive Care, Bielefeld Clinicum, 
      Academic Teaching Hospital of the University of Muenster, Bielefeld, Germany. 
      gietzen@t-online.de
FAU - Leuner, C J
AU  - Leuner CJ
FAU - Obergassel, L
AU  - Obergassel L
FAU - Strunk-Mueller, C
AU  - Strunk-Mueller C
FAU - Kuhn, H
AU  - Kuhn H
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PL  - England
TA  - Heart
JT  - Heart (British Cardiac Society)
JID - 9602087
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Angioplasty, Balloon, Coronary/*methods
MH  - Cardiac Catheterization/methods
MH  - Cardiomyopathy, Hypertrophic/mortality/physiopathology/*therapy
MH  - Catheter Ablation/*methods
MH  - Exercise/physiology
MH  - Feasibility Studies
MH  - Female
MH  - Heart Septum
MH  - Hemodynamics/physiology
MH  - Hospital Mortality
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Treatment Outcome
PMC - PMC1768263
EDAT- 2004/05/18 05:00
MHDA- 2004/06/16 05:00
PMCR- 2007/06/01
CRDT- 2004/05/18 05:00
PHST- 2004/05/18 05:00 [pubmed]
PHST- 2004/06/16 05:00 [medline]
PHST- 2004/05/18 05:00 [entrez]
PHST- 2007/06/01 00:00 [pmc-release]
AID - 0900638 [pii]
AID - 10.1136/hrt.2003.017509 [doi]
PST - ppublish
SO  - Heart. 2004 Jun;90(6):638-44. doi: 10.1136/hrt.2003.017509.