PMID- 15146350
OWN - NLM
STAT- MEDLINE
DCOM- 20041008
LR  - 20131121
IS  - 0303-4240 (Print)
IS  - 0303-4240 (Linking)
VI  - 151
DP  - 2004
TI  - The epithelial sodium channel: from molecule to disease.
PG  - 93-107
AB  - Genetic analysis has demonstrated that Na absorption in the aldosterone-sensitive 
      distal nephron (ASDN) critically determines extracellular blood volume and blood 
      pressure variations. The epithelial sodium channel (ENaC) represents the main 
      transport pathway for Na+ absorption in the ASDN, in particular in the connecting 
      tubule (CNT), which shows the highest capacity for ENaC-mediated Na+ absorption. 
      Gain-of-function mutations of ENaC causing hypertension target an intracellular 
      proline-rich sequence involved in the control of ENaC activity at the cell 
      surface. In animal models, these ENaC mutations exacerbate Na+ transport in 
      response to aldosterone, an effect that likely plays an important role in the 
      development of volume expansion and hypertension. Recent studies of the 
      functional consequences of mutations in genes controlling Na+ absorption in the 
      ASDN provide a new understanding of the molecular and cellular mechanisms 
      underlying the pathogenesis of salt-sensitive hypertension.
FAU - Schild, L
AU  - Schild L
AD  - Department of Pharmacology and Toxicology, University of Lausanne, Rue du Bugnon 
      27, 1005 Lausanne, Switzerland. Laurent.Schild@ipharm.unil.ch
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20040514
PL  - Germany
TA  - Rev Physiol Biochem Pharmacol
JT  - Reviews of physiology, biochemistry and pharmacology
JID - 0434624
RN  - 0 (Epithelial Sodium Channels)
RN  - 0 (Salts)
RN  - 0 (Sodium Channels)
RN  - 4964P6T9RB (Aldosterone)
RN  - 9DLQ4CIU6V (Proline)
RN  - 9NEZ333N27 (Sodium)
SB  - IM
MH  - Aldosterone/metabolism
MH  - Amino Acid Motifs
MH  - Animals
MH  - Biological Transport
MH  - Epithelial Sodium Channels
MH  - Humans
MH  - Kidney/metabolism
MH  - Mutation
MH  - Proline/chemistry
MH  - Salts/pharmacology
MH  - Sodium/metabolism
MH  - Sodium Channels/*metabolism/*physiology
RF  - 85
EDAT- 2004/05/18 05:00
MHDA- 2004/10/09 09:00
CRDT- 2004/05/18 05:00
PHST- 2004/05/18 05:00 [pubmed]
PHST- 2004/10/09 09:00 [medline]
PHST- 2004/05/18 05:00 [entrez]
AID - 10.1007/s10254-004-0023-7 [doi]
PST - ppublish
SO  - Rev Physiol Biochem Pharmacol. 2004;151:93-107. doi: 10.1007/s10254-004-0023-7. 
      Epub 2004 May 14.