PMID- 15146951
OWN - NLM
STAT- MEDLINE
DCOM- 20040719
LR  - 20131121
IS  - 1295-0661 (Print)
IS  - 1295-0661 (Linking)
VI  - 198
IP  - 1
DP  - 2004
TI  - [Genetic models to understand how serotonin acts during development].
PG  - 18-21
AB  - Molecular genetics in mice have allowed significant progresses to be made in our 
      understanding of the development of serotoninergic neurones and of their 
      developmental role. The serotoninergic phenotype is determined by a sequence of 
      transcription factors. Pet-1 is selectively expressed in the raphe and controls 
      directly the transcription of the genes, encoding the biosynthetic enzyme of 
      5-HT, tryptophan hydroxylase (TPH), and the serotonin plasma membrane transporter 
      (SERT). Expression of SERT can however occur independently of TPH during 
      development and allows subpopulations of glutamatergic neurons to take up and to 
      store 5-HT into synaptic vesicles via the vesicular monoamine transporter (VMAT). 
      This could allow a tight homeostasis of 5-HT receptor activation on thalamic and 
      retinal afferents. Mice with an excess or a severe reduction of 5-HT during 
      development, such as the MAOA and the VMAT2 KO mice, show abnormalities that 
      concern late stages of development: alterations in axon branching, dendritic 
      remodeling and developmental cell death. Each of these effects could be mediated 
      by a different 5-HT receptor. Abnormalities have been best characterized in the 
      somatosensory and visual system but are likely to occur throughout the central 
      nervous system.
FAU - Gaspar, Patricia
AU  - Gaspar P
AD  - INSERM Unite 106, Batiment Pediatrie, Hopital de la Salpetriere, 47, boulevard de 
      l'Hopital, 75651 Paris 13. gaspar@infobiogen.fr
LA  - fre
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Des modeles genetiques pour comprendre le role de la serotonine au cours du 
      developpement.
PL  - France
TA  - J Soc Biol
JT  - Journal de la Societe de biologie
JID - 100890617
RN  - 0 (Carrier Proteins)
RN  - 0 (Fev protein, mouse)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Membrane Transport Proteins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Receptors, Serotonin)
RN  - 0 (Serotonin Plasma Membrane Transport Proteins)
RN  - 0 (Slc6a4 protein, mouse)
RN  - 0 (Transcription Factors)
RN  - 333DO1RDJY (Serotonin)
RN  - EC 1.14.16.4 (Tryptophan Hydroxylase)
SB  - IM
MH  - Animals
MH  - Carrier Proteins/biosynthesis/genetics
MH  - Enzyme Induction
MH  - *Gene Expression Regulation, Developmental
MH  - Homeostasis
MH  - Membrane Glycoproteins/biosynthesis/genetics
MH  - *Membrane Transport Proteins
MH  - Mice
MH  - Mice, Knockout
MH  - *Models, Genetic
MH  - Nerve Tissue Proteins/biosynthesis/genetics
MH  - Nervous System/embryology
MH  - Nervous System Malformations/embryology/genetics
MH  - Neurons/classification/*metabolism
MH  - Phenotype
MH  - Receptors, Serotonin/genetics/physiology
MH  - Serotonin/deficiency/*physiology
MH  - Serotonin Plasma Membrane Transport Proteins
MH  - Transcription Factors/physiology
MH  - Tryptophan Hydroxylase/biosynthesis/genetics
RF  - 22
EDAT- 2004/05/19 05:00
MHDA- 2004/07/20 05:00
CRDT- 2004/05/19 05:00
PHST- 2004/05/19 05:00 [pubmed]
PHST- 2004/07/20 05:00 [medline]
PHST- 2004/05/19 05:00 [entrez]
PST - ppublish
SO  - J Soc Biol. 2004;198(1):18-21.