PMID- 15147144 OWN - NLM STAT- MEDLINE DCOM- 20041116 LR - 20161018 IS - 1434-6621 (Print) IS - 1434-6621 (Linking) VI - 42 IP - 4 DP - 2004 Apr TI - Intravenous immunoglobulin (IVIG): modes of action in the clinical management of recurrent pregnancy loss (RPL) and selected autoimmune disorders. PG - 359-70 AB - Recurrent pregnancy loss has been associated with autoimmune responses to membrane phospholipids and alloimmune reactions against paternally derived molecules on the trophoblast. The problem is psychologically and economically stressful as it undermines the capacity of some couples to reproduce and participate effectively in the day-to-day economic activities. This article reviews the adoption of intravenous immunoglobulin as a form of therapy for the clinical management of recurrent pregnancy loss and of selected autoimmune disorders. Side effects, contraindications and safety of use are discussed. FAU - Omwandho, Charles O A AU - Omwandho CO AD - Department of Biochemistry, University of Nairobi, Nairobi, Kenya. FAU - Gruessner, Susanne E M AU - Gruessner SE FAU - Roberts, Timothy K AU - Roberts TK FAU - Tinneberg, Hans Rudolf AU - Tinneberg HR LA - eng PT - Journal Article PT - Review PL - Germany TA - Clin Chem Lab Med JT - Clinical chemistry and laboratory medicine JID - 9806306 RN - 0 (Immunoglobulins, Intravenous) SB - IM MH - Abortion, Habitual/immunology/*therapy MH - Autoimmune Diseases/immunology/*therapy MH - Female MH - Humans MH - Immunoglobulins, Intravenous/*therapeutic use MH - *Immunotherapy MH - Pregnancy MH - Pregnancy Complications/immunology/therapy RF - 100 EDAT- 2004/05/19 05:00 MHDA- 2004/11/17 09:00 CRDT- 2004/05/19 05:00 PHST- 2004/05/19 05:00 [pubmed] PHST- 2004/11/17 09:00 [medline] PHST- 2004/05/19 05:00 [entrez] AID - 10.1515/CCLM.2004.065 [doi] PST - ppublish SO - Clin Chem Lab Med. 2004 Apr;42(4):359-70. doi: 10.1515/CCLM.2004.065.