PMID- 15147436
OWN - NLM
STAT- MEDLINE
DCOM- 20041209
LR  - 20230124
IS  - 1600-6135 (Print)
IS  - 1600-6135 (Linking)
VI  - 4
IP  - 6
DP  - 2004 Jun
TI  - Sirolimus-induced angioedema.
PG  - 1002-5
AB  - Sirolimus (SRL) is a macrolide immunosuppressant that has gained widespread use 
      in organ transplantation. Its full spectrum of side-effects is yet to be defined. 
      We describe herein three cases of SRL-induced angioedema (AE) in African-American 
      (AA) primary renal allograft recipients who received SRL in combination with 
      mycophenolate mofetil and steroids. In two cases, AE manifested after SRL was 
      restarted after a period of discontinuation. The third case presented upon 
      initial exposure to the drug. None of the patients was receiving any drug that 
      has been previously associated with AE. Complete resolution occurred only after 
      SRL was withdrawn. AE has not recurred in any of the patients during a follow-up 
      period of up to 21 months. We conclude that AE is a previously unrecognized 
      adverse event associated with SRL use. Close monitoring for this side-effect, 
      especially in AA patients, is warranted.
FAU - Wadei, Hani
AU  - Wadei H
AD  - Division of Nephrology, Department of Medicine, Wayne State University School of 
      Medicine, Detroit, MI, USA.
FAU - Gruber, Scott A
AU  - Gruber SA
FAU - El-Amm, Jose M
AU  - El-Amm JM
FAU - Garnick, James
AU  - Garnick J
FAU - West, Miguel S
AU  - West MS
FAU - Granger, Darla K
AU  - Granger DK
FAU - Sillix, Dale H
AU  - Sillix DH
FAU - Migdal, Stephen D
AU  - Migdal SD
FAU - Haririan, Abdolreza
AU  - Haririan A
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Am J Transplant
JT  - American journal of transplantation : official journal of the American Society of 
      Transplantation and the American Society of Transplant Surgeons
JID - 100968638
RN  - 0 (Immunosuppressive Agents)
RN  - HU9DX48N0T (Mycophenolic Acid)
RN  - W36ZG6FT64 (Sirolimus)
SB  - IM
MH  - Black or African American
MH  - Angioedema/*chemically induced
MH  - Drug Therapy, Combination
MH  - Follow-Up Studies
MH  - Humans
MH  - Immunosuppressive Agents/*adverse effects
MH  - *Kidney Transplantation
MH  - Male
MH  - Middle Aged
MH  - Mycophenolic Acid/adverse effects/*analogs & derivatives
MH  - Postoperative Care
MH  - Retreatment
MH  - Sirolimus/*adverse effects
MH  - Transplantation, Homologous
EDAT- 2004/05/19 05:00
MHDA- 2004/12/16 09:00
CRDT- 2004/05/19 05:00
PHST- 2004/05/19 05:00 [pubmed]
PHST- 2004/12/16 09:00 [medline]
PHST- 2004/05/19 05:00 [entrez]
AID - S1600-6135(22)07555-4 [pii]
AID - 10.1111/j.1600-6143.2004.00429.x [doi]
PST - ppublish
SO  - Am J Transplant. 2004 Jun;4(6):1002-5. doi: 10.1111/j.1600-6143.2004.00429.x.