PMID- 15147449
OWN - NLM
STAT- MEDLINE
DCOM- 20041012
LR  - 20071114
IS  - 0105-4538 (Print)
IS  - 0105-4538 (Linking)
VI  - 59
IP  - 6
DP  - 2004 Jun
TI  - Comparison of local risk factors for children's atopic symptoms in Hanoi, 
      Vietnam.
PG  - 637-44
AB  - BACKGROUND: A 1999 study in Hanoi, Vietnam using the International Study on 
      Asthma and Allergies in Childhood (ISAAC) questionnaire showed a high prevalence 
      of atopic symptoms. Identifying risk factors for symptoms in these children may 
      help in understanding the causes for these high estimates. METHODS: An ISAAC 
      questionnaire with supplemental questions on environmental variables was 
      distributed to 5495 school children in Hanoi and a suburban district, Dong Anh. 
      The response rate was 65.7%. RESULTS: In Dong Anh, the following were among the 
      significant age and gender adjusted associations: pig ownership [odds ratio (OR) 
      (95% confidence interval), OR = 1.79 (1.18-2.70) for doctor-diagnosed asthma 
      (DDA), OR = 1.72 (1.08-2.78) for doctor diagnosed hay fever (DDHF)] and farming 
      [OR = 1.67 (1.27-2.19) for ever asthma, OR = 1.51 (1.09-2.09) for DDHF]. In 
      multivariate models, tuberculosis (TB) was a significant predictor of atopic 
      symptoms [Hanoi: OR = 3.09 (1.10-8.70) for DDA, Dong Anh: OR = 3.71 (1.40-9.84) 
      for DDA, OR = 4.66 (1.88-11.57) for DDHF]. CONCLUSIONS: These findings are 
      contrary to the "hygiene hypothesis". Recent immunologic and epidemiologic 
      studies refute the inverse association between allergy and TB and may be one 
      explanation for the positive association in this study. The positive association 
      with pig ownership and farming may be because of exposures on farms in a 
      developing country that may be different from exposures in farms of developed 
      countries.
FAU - Chai, S K
AU  - Chai SK
AD  - Department of Environmental and Occupational Health Sciences, University of 
      Washington, Seattle, WA, USA.
FAU - Nga, N N
AU  - Nga NN
FAU - Checkoway, H
AU  - Checkoway H
FAU - Takaro, T K
AU  - Takaro TK
FAU - Redding, G J
AU  - Redding GJ
FAU - Keifer, M C
AU  - Keifer MC
FAU - Trung, L V
AU  - Trung LV
FAU - Barnhart, S
AU  - Barnhart S
LA  - eng
GR  - 3D43 TW 00642-05S1/TW/FIC NIH HHS/United States
GR  - T32 ES 07262/ES/NIEHS NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Cross-Sectional Studies
MH  - Developing Countries
MH  - Female
MH  - Humans
MH  - Hypersensitivity/*epidemiology
MH  - Male
MH  - Risk Factors
MH  - Socioeconomic Factors
MH  - Suburban Population
MH  - Urban Population
MH  - Vietnam/epidemiology
EDAT- 2004/05/19 05:00
MHDA- 2004/10/13 09:00
CRDT- 2004/05/19 05:00
PHST- 2004/05/19 05:00 [pubmed]
PHST- 2004/10/13 09:00 [medline]
PHST- 2004/05/19 05:00 [entrez]
AID - ALL463 [pii]
AID - 10.1111/j.1398-9995.2004.00463.x [doi]
PST - ppublish
SO  - Allergy. 2004 Jun;59(6):637-44. doi: 10.1111/j.1398-9995.2004.00463.x.