PMID- 15148809
OWN - NLM
STAT- MEDLINE
DCOM- 20040727
LR  - 20181130
IS  - 0047-1852 (Print)
IS  - 0047-1852 (Linking)
VI  - 62
IP  - 5
DP  - 2004 May
TI  - [Familial tumor syndrome and ectopic hormone-producing tumors].
PG  - 851-63
AB  - It has been thought that endocrine tumors occurred through interactions of 
      multiple environments factors and a personal genetic factor. A normal somatic 
      cell having an intrinsic function is able to obtain the character of a malignant 
      cell by influence of many factors. Several percent of all tumors have obvious 
      familial aggregation. These entity are called familial cancer. Familial cancer 
      syndrome is well defined for colorectal cancer and breast cancer, but an 
      endocrine neoplasia is the one, too. Ectopic hormone producing tumors are kinds 
      of endocrine tumors, and have the characteristics, which they generate in many 
      organs multicentrically. The phenomena suggest that the patient with these 
      disorders may possess strong genetic predisposition. Among endocrine neoplasia, 
      multiple endocrine neoplasia type 1 (MEN1), multiple endocrine neoplasia type 2 
      (MEN2), von Hippel-Lindau disease(VHL) are well defined genetic disorder with 
      autosomal dominant inheritance, and the reliable genes were previously identified 
      as MEN1, RET, and VHL, respectively. At this opportunity, we interpret for these 
      three disorders.
FAU - Tamura, Kazuo
AU  - Tamura K
AD  - Laboratory of Hereditary Tumor, Institute for Advanced Medical Sciences, Hyogo 
      College of Medicine.
FAU - Utsunomiya, Joji
AU  - Utsunomiya J
FAU - Yamamura, Takehira
AU  - Yamamura T
LA  - jpn
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Nihon Rinsho
JT  - Nihon rinsho. Japanese journal of clinical medicine
JID - 0420546
RN  - 0 (Hormones, Ectopic)
SB  - IM
MH  - Base Pair Mismatch/genetics
MH  - DNA Repair/genetics
MH  - Genes, Tumor Suppressor
MH  - Hormones, Ectopic/*metabolism
MH  - Humans
MH  - Molecular Diagnostic Techniques
MH  - Multiple Endocrine Neoplasia/diagnosis/*genetics/metabolism
MH  - Neoplasms/diagnosis/*genetics/metabolism
MH  - Oncogenes/genetics
MH  - von Hippel-Lindau Disease/genetics
RF  - 17
EDAT- 2004/05/20 05:00
MHDA- 2004/07/28 05:00
CRDT- 2004/05/20 05:00
PHST- 2004/05/20 05:00 [pubmed]
PHST- 2004/07/28 05:00 [medline]
PHST- 2004/05/20 05:00 [entrez]
PST - ppublish
SO  - Nihon Rinsho. 2004 May;62(5):851-63.