PMID- 15149874
OWN - NLM
STAT- MEDLINE
DCOM- 20050216
LR  - 20191210
IS  - 0009-8981 (Print)
IS  - 0009-8981 (Linking)
VI  - 344
IP  - 1-2
DP  - 2004 Jun
TI  - Detection of bone marrow infiltration of lymphoma cells by fluorescence in situ 
      hybridization.
PG  - 79-82
AB  - BACKGROUND: It is sometimes difficult to detect the bone marrow infiltration of 
      lymphoma cells, because lymphoma cells are not distinguishable from normal 
      lymphocytes due to the similarity of their phenotype. METHODS: Bone marrow 
      involvement of 17 samples of 15 patients with follicular lymphoma, whose lymphoma 
      cells were confirmed to harbor the translocation of chromosome14q32, were 
      examined by microscopic analysis of bone marrow smear and biopsy, flow 
      cytometorical analysis (FCM), chromosomal analysis of G-banding and fluorescence 
      in situ hybridization (FISH). FISH was performed using a probe, which detects the 
      split of IGH gene on 14q32. RESULTS: The positivity of FISH was highest among 
      these methods and FISH was able to detect the bone marrow involvement in one case 
      who was defined as negative by bone marrow biopsy. CONCLUSIONS: FISH can be used 
      for detection of bone marrow involvement of malignant lymphoma that carries 
      chromosomal rearrangement involving 14q32.
CI  - Copyright 2004 Elsevier B.V.
FAU - Ishizawa, Kenichi
AU  - Ishizawa K
AD  - Department of Rheumatology and Hematology, 1-1 Seiryo-machi, Aoba-ku, Sendai 
      980-8574, Japan.
FAU - Obara, Yasuhiko
AU  - Obara Y
FAU - Seki, Osamu
AU  - Seki O
FAU - Fujimaki, Shinichi
AU  - Fujimaki S
FAU - Kameoka, Junichi
AU  - Kameoka J
FAU - Ichinohasama, Ryo
AU  - Ichinohasama R
FAU - Kanemitsu, Keiji
AU  - Kanemitsu K
FAU - Sasaki, Takeshi
AU  - Sasaki T
FAU - Kaku, Mitsuo
AU  - Kaku M
FAU - Harigae, Hideo
AU  - Harigae H
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Clin Chim Acta
JT  - Clinica chimica acta; international journal of clinical chemistry
JID - 1302422
SB  - IM
MH  - Bone Marrow/*pathology
MH  - Bone Marrow Examination
MH  - Chromosome Banding
MH  - Chromosomes, Human, Pair 14
MH  - Flow Cytometry
MH  - Humans
MH  - *In Situ Hybridization, Fluorescence
MH  - Lymphoma/*pathology
MH  - Lymphoma, Follicular/pathology
MH  - Neoplasm Invasiveness/pathology
MH  - Translocation, Genetic
EDAT- 2004/05/20 05:00
MHDA- 2005/02/17 09:00
CRDT- 2004/05/20 05:00
PHST- 2003/11/24 00:00 [received]
PHST- 2004/02/08 00:00 [revised]
PHST- 2004/02/08 00:00 [accepted]
PHST- 2004/05/20 05:00 [pubmed]
PHST- 2005/02/17 09:00 [medline]
PHST- 2004/05/20 05:00 [entrez]
AID - S0009898104001007 [pii]
AID - 10.1016/j.cccn.2004.02.014 [doi]
PST - ppublish
SO  - Clin Chim Acta. 2004 Jun;344(1-2):79-82. doi: 10.1016/j.cccn.2004.02.014.