PMID- 15150143
OWN - NLM
STAT- MEDLINE
DCOM- 20050125
LR  - 20091119
IS  - 0379-864X (Print)
IS  - 0379-864X (Linking)
VI  - 29
IP  - 4
DP  - 2004 May
TI  - Morphological evidence for two types of Mammalian vomeronasal system.
PG  - 301-10
AB  - The vomeronasal (VN) systems of rodents and opossums are of the segregated type, 
      i.e alpha-subtype G protein Gi2- or Go-expressing VN neurons, which are sensory 
      cells, project discretely to the rostral or caudal region of the accessory 
      olfactory bulb (AOB). Although this zone-specific projection is believed to be a 
      common feature for processing pheromones in mammals, we previously found a 
      uniform-type VN system in goat in which only Gi2-expressing VN axons terminate at 
      the AOB. In most mammals, it remains unclear whether their VN systems are of the 
      segregated or uniform type. Therefore, we investigated morphologically the VN 
      systems of different mammalian species (dog, horse, musk shrew and common 
      marmoset). Consequently, all VN axons of the examined animals were positively 
      stained with immunohistochemistry for Gi2 in the same way as that in the goat. On 
      the other hand, we observed immunoreactivities against Go in the olfactory axons, 
      but not in the VN axons. These results suggest that many mammals have 
      uniform-type VN systems, and at least two types of VN systems exist in 
      terrestrial mammals. This morphological evidence will help us determine the 
      processing function of VN systems.
FAU - Takigami, Shu
AU  - Takigami S
AD  - Department of Basic Technics and Facilities, Tokyo Metropolitan Institute for 
      Neuroscience, 2-6 Musashidai, Fuchu, Tokyo 183-8526, Japan.
FAU - Mori, Yuji
AU  - Mori Y
FAU - Tanioka, Yoshikuni
AU  - Tanioka Y
FAU - Ichikawa, Masumi
AU  - Ichikawa M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Chem Senses
JT  - Chemical senses
JID - 8217190
RN  - 0 (Proto-Oncogene Proteins)
RN  - EC 3.6.5.1 (GTP-Binding Protein alpha Subunit, Gi2)
RN  - EC 3.6.5.1 (GTP-Binding Protein alpha Subunits, Gi-Go)
SB  - IM
MH  - Animals
MH  - Callithrix
MH  - Cross Reactions
MH  - Dogs
MH  - Female
MH  - GTP-Binding Protein alpha Subunit, Gi2
MH  - GTP-Binding Protein alpha Subunits, Gi-Go/chemistry/immunology
MH  - Guinea Pigs
MH  - Horses/anatomy & histology
MH  - Immunohistochemistry
MH  - Male
MH  - Olfactory Bulb/*anatomy & histology
MH  - Proto-Oncogene Proteins/chemistry/immunology
MH  - Shrews
MH  - Vomeronasal Organ/*anatomy & histology
EDAT- 2004/05/20 05:00
MHDA- 2005/01/26 09:00
CRDT- 2004/05/20 05:00
PHST- 2004/05/20 05:00 [pubmed]
PHST- 2005/01/26 09:00 [medline]
PHST- 2004/05/20 05:00 [entrez]
AID - 29/4/301 [pii]
AID - 10.1093/chemse/bjh032 [doi]
PST - ppublish
SO  - Chem Senses. 2004 May;29(4):301-10. doi: 10.1093/chemse/bjh032.