PMID- 15153312
OWN - NLM
STAT- MEDLINE
DCOM- 20050127
LR  - 20061115
IS  - 1079-9907 (Print)
IS  - 1079-9907 (Linking)
VI  - 24
IP  - 5
DP  - 2004 May
TI  - Differential upregulation of interleukin-18 receptor alpha chain between CD4+ and 
      CD8+ T cells during acute graft-versus-host disease in mice.
PG  - 291-6
AB  - Interleukin-18 (IL-18), a unique cytokine that stimulates both T helper 1 (Th1) 
      and Th2 responses, is associated with acute graft-versus-host disease (aGVHD), 
      the major limiting toxicity following allogeneic stem cell transplantation. Here, 
      we investigated the mechanism underlying the upregulation of IL-18 receptor 
      (IL-18R) expression on T cells in murine aGVHD models. The induction of aGVHD 
      elevated host serum IL-12 levels and increased expression of IL-18Ralpha chain 
      (IL-18Ralpha) on engrafted T cells, in particular on CD8+ T cells. However, 
      IL-18Ralpha expression did not increase on the CD4+ T cells of an IL-12-deficient 
      host, indicating the IL-12-dependent upregulation of IL-18Ralpha expression on 
      CD4+ T cells during aGVHD. Purified donor CD8+ T cells transferred in the host 
      increased IL-18Ralpha expression. In vitro experiments showed that IL-18Ralpha 
      expression upregulated on CD8+ T cells but not on CD4+ T cells on stimulation 
      through the T cell receptor (TCR). These results suggest that IL-18Ralpha 
      expression is differentially upregulated between CD4+ and CD8+ T cells during 
      aGVHD, depending on endogenous IL-12 and TCR engagement, respectively.
FAU - Itoi, Hisayuki
AU  - Itoi H
AD  - Department of Internal Medicine, Hyogo College of Medicine, 1-1 Mukogawa-cho, 
      Nishinomiya, Hyogo 663-8501, Japan.
FAU - Fujimori, Yoshihiro
AU  - Fujimori Y
FAU - Tsutsui, Hiroko
AU  - Tsutsui H
FAU - Matsui, Kiyoshi
AU  - Matsui K
FAU - Hada, Toshikazu
AU  - Hada T
FAU - Kakishita, Eizo
AU  - Kakishita E
FAU - Okamura, Haruki
AU  - Okamura H
FAU - Hara, Hiroshi
AU  - Hara H
FAU - Nakanishi, Kenji
AU  - Nakanishi K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Interferon Cytokine Res
JT  - Journal of interferon & cytokine research : the official journal of the 
      International Society for Interferon and Cytokine Research
JID - 9507088
RN  - 0 (Il18r1 protein, mouse)
RN  - 0 (Interleukin-18 Receptor alpha Subunit)
RN  - 0 (Receptors, Antigen, T-Cell)
RN  - 0 (Receptors, Interleukin)
RN  - 0 (Receptors, Interleukin-18)
RN  - 187348-17-0 (Interleukin-12)
SB  - IM
MH  - Acute Disease
MH  - Animals
MH  - CD4-Positive T-Lymphocytes/*immunology
MH  - CD8-Positive T-Lymphocytes/*immunology
MH  - Cell Transplantation
MH  - Female
MH  - Gene Expression Regulation/immunology
MH  - Graft vs Host Disease/*immunology/metabolism
MH  - Interleukin-12/immunology
MH  - Interleukin-18 Receptor alpha Subunit
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Receptors, Antigen, T-Cell/immunology
MH  - Receptors, Interleukin/biosynthesis/*immunology
MH  - Receptors, Interleukin-18
MH  - Spleen/cytology/transplantation
MH  - Th1 Cells/immunology
MH  - Th2 Cells/immunology
MH  - Transplantation Chimera/immunology
MH  - Up-Regulation
EDAT- 2004/05/22 05:00
MHDA- 2005/01/28 09:00
CRDT- 2004/05/22 05:00
PHST- 2004/05/22 05:00 [pubmed]
PHST- 2005/01/28 09:00 [medline]
PHST- 2004/05/22 05:00 [entrez]
AID - 10.1089/107999004323065075 [doi]
PST - ppublish
SO  - J Interferon Cytokine Res. 2004 May;24(5):291-6. doi: 10.1089/107999004323065075.