PMID- 15153465
OWN - NLM
STAT- MEDLINE
DCOM- 20040806
LR  - 20190516
IS  - 0022-1767 (Print)
IS  - 0022-1767 (Linking)
VI  - 172
IP  - 11
DP  - 2004 Jun 1
TI  - Cutting edge: hemokinin has substance P-like function and expression in 
      inflammation.
PG  - 6528-32
AB  - Substance P (SP) belongs to the tachykinin family of molecules. SP, cleaved from 
      preprotachykinin A, is a neuropeptide and a proinflammatory leukocyte product. SP 
      engages neurokinin 1 receptor (NK-1R) to stimulate cells. Hemokinin (HK) is 
      another tachykinin that binds NK-1R. HK comes from preprotachykinin C, which is 
      distinct from preprotachykinin A. We determined whether HK functions like SP at 
      inflammatory sites. Preprotachykinin C mRNA was in murine schistosome granulomas 
      and intestinal lamina propria mononuclear cells. Granuloma T cells and 
      macrophages expressed preprotachykinin C mRNA. HK bound granuloma T cell NK-1R 
      with high affinity. SP and HK stimulated IFN-gamma production with equal potency. 
      NK-1R antagonist blocked the effect of SP and HK on IFN-gamma secretion. Thus, 
      both HK and SP are expressed at sites of chronic inflammation and share cell 
      origin, receptor, and immunoregulatory function. Two distinct but functionally 
      overlapping tachykinins govern inflammation through NK-1R at sites of chronic 
      inflammation.
FAU - Metwali, Ahmed
AU  - Metwali A
AD  - Department of Internal Medicine, Division of Gastroenterology-Hepatology, 
      University of Iowa, Iowa City, IA 52242, USA.
FAU - Blum, Arthur M
AU  - Blum AM
FAU - Elliott, David E
AU  - Elliott DE
FAU - Setiawan, Tommy
AU  - Setiawan T
FAU - Weinstock, Joel V
AU  - Weinstock JV
LA  - eng
GR  - DK07663/DK/NIDDK NIH HHS/United States
GR  - DK25295/DK/NIDDK NIH HHS/United States
GR  - DK38327/DK/NIDDK NIH HHS/United States
GR  - DK58755/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Immunol
JT  - Journal of immunology (Baltimore, Md. : 1950)
JID - 2985117R
RN  - 0 (Protein Precursors)
RN  - 0 (Receptors, Neurokinin-1)
RN  - 0 (Tac4 protein, mouse)
RN  - 0 (Tachykinins)
RN  - 0 (preprotachykinin)
RN  - 33507-63-0 (Substance P)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Animals
MH  - Cell Line
MH  - Inflammation/*metabolism
MH  - Interferon-gamma/biosynthesis
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Inbred CBA
MH  - Protein Precursors/genetics/*physiology
MH  - Receptors, Neurokinin-1/metabolism
MH  - Substance P/*physiology
MH  - Tachykinins/genetics/*physiology
EDAT- 2004/05/22 05:00
MHDA- 2004/08/07 05:00
CRDT- 2004/05/22 05:00
PHST- 2004/05/22 05:00 [pubmed]
PHST- 2004/08/07 05:00 [medline]
PHST- 2004/05/22 05:00 [entrez]
AID - 10.4049/jimmunol.172.11.6528 [doi]
PST - ppublish
SO  - J Immunol. 2004 Jun 1;172(11):6528-32. doi: 10.4049/jimmunol.172.11.6528.