PMID- 15154876
OWN - NLM
STAT- MEDLINE
DCOM- 20041202
LR  - 20061107
IS  - 1744-9979 (Print)
IS  - 1744-9979 (Linking)
VI  - 8
IP  - 3
DP  - 2004 Jun
TI  - A case report of the efficacy of apheresis for refractory autoimmune 
      thrombocytopenia in a patient with systemic lupus erythematosus associated 
      hemolytic anemia.
PG  - 227-31
AB  - Autoantibodies against platelets are found in patients with autoimmune 
      thrombocytopenic purpura (AITP) as well as in thrombocytopenia associated with 
      systemic lupus erythematosus (SLE). The high titer of platelet associated 
      immunoglobulin G (PA IgG) suggests the presence of antibodies against platelets. 
      Platelet associated antibodies are thought to play a major role in the 
      pathogenesis of autoimmune thrombocytopenia. There is a possibility that double 
      filtration plasmapheresis (DFPP) is effective in removing the antibodies against 
      platelets from the peripheral blood. It is suggested that DFPP may reinforce the 
      efforts of the conventional treatment, especially high-dose intravenous 
      immunoglobulin therapy (IVIg). DFPP was performed for severe thrombocytopenia on 
      a SLE patient with high PA IgG value, refractory to the conventional therapy 
      including corticosteroid therapy and IVIg. The patient underwent three sessions 
      of DFPP combined with IVIg and the corticosteroid therapy immediately before the 
      initiation of IVIg. The severe thrombocytopenia improved drastically after the 
      combination treatment, accompanied with the decrease of the PA IgG titer. It was 
      suggested that DFPP combined with corticosteroid and IVIg was effective for 
      severe autoimmune thrombocytopenia on SLE patients refractory to the conventional 
      therapies.
FAU - Yamaji, Ken
AU  - Yamaji K
AD  - Department of Internal Medicine and Rheumatology, Juntendo University, Tokyo, 
      Japan. k.yamaji@med.juntendo.ac.jp
FAU - Tsuda, Hiroshi
AU  - Tsuda H
FAU - Hashimoto, Hiroshi
AU  - Hashimoto H
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Australia
TA  - Ther Apher Dial
JT  - Therapeutic apheresis and dialysis : official peer-reviewed journal of the 
      International Society for Apheresis, the Japanese Society for Apheresis, the 
      Japanese Society for Dialysis Therapy
JID - 101181252
RN  - 0 (Immunoglobulin G)
SB  - IM
MH  - Adult
MH  - Anemia, Hemolytic/etiology/*therapy
MH  - Blood Component Removal/*methods
MH  - Female
MH  - Humans
MH  - Immunoglobulin G/blood
MH  - Lupus Erythematosus, Systemic/*complications
MH  - Platelet Count
MH  - Purpura, Thrombocytopenic, Idiopathic/etiology/*therapy
MH  - Treatment Outcome
EDAT- 2004/05/25 05:00
MHDA- 2004/12/16 09:00
CRDT- 2004/05/25 05:00
PHST- 2004/05/25 05:00 [pubmed]
PHST- 2004/12/16 09:00 [medline]
PHST- 2004/05/25 05:00 [entrez]
AID - TAP152 [pii]
AID - 10.1111/j.1526-0968.2004.00152.x [doi]
PST - ppublish
SO  - Ther Apher Dial. 2004 Jun;8(3):227-31. doi: 10.1111/j.1526-0968.2004.00152.x.