PMID- 15157013
OWN - NLM
STAT- MEDLINE
DCOM- 20040615
LR  - 20220318
IS  - 0931-184X (Print)
IS  - 0931-184X (Linking)
VI  - 50
IP  - 10
DP  - 2003 Dec
TI  - Cardiovascular effects of xylazine recorded with telemetry in the dog.
PG  - 479-83
AB  - Cardiovascular effects of xylazine have not been studied with telemetry in dogs. 
      In the present study, the effects on cardiovascular parameters after 
      intramuscular (i.m.) administration of 2.0 mg/kg xylazine were studied via 
      telemetry in unrestrained dogs. Telemetry transmitters were implanted 
      subcutaneously (s.c.) with a pressure catheter in the femoral artery. 
      Cardiovascular effects and body temperature effects were assessed after i.m. 
      administration of xylazine. Heart rate decreased for about 10 min and was 
      continuously depressed during 60 min. Thereafter, heart rate slowly increased but 
      had not fully reached pre-dose values 4 h after treatment. Both systolic and 
      diastolic blood pressure increased immediately after administration of xylazine. 
      The systolic blood pressure showed a peak increase for about 5-10 min and then 
      decreased below the baseline value not normalizing within 90 min. The diastolic 
      blood pressure peaked 5-10 min after xylazine administration but did not return 
      to baseline level until 50 min after administration. Body temperature decreased 
      continuously for about 90 min and remained low for more than 4 h after treatment. 
      An additional administration of xylazine to the same individuals after a recovery 
      period of 4 weeks induced exactly the same response in systolic and diastolic 
      blood pressure and in heart rate. By using the telemetric recording system it was 
      possible to continuously evaluate xylazine-induced cardiovascular responses in a 
      way that is not possible with conventional techniques.
FAU - Ilback, N G
AU  - Ilback NG
AD  - Toxicology Division, National Food Administration, Uppsala, Sweden. 
      nils-gunnar.ilback@slv.se
FAU - Stalhandske, T
AU  - Stalhandske T
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - J Vet Med A Physiol Pathol Clin Med
JT  - Journal of veterinary medicine. A, Physiology, pathology, clinical medicine
JID - 100955112
RN  - 0 (Adrenergic alpha-Agonists)
RN  - 2KFG9TP5V8 (Xylazine)
SB  - IM
MH  - Adrenergic alpha-Agonists/administration & dosage/*pharmacology
MH  - Animals
MH  - Blood Pressure/drug effects
MH  - Dogs/*physiology
MH  - Female
MH  - Heart Rate/*drug effects
MH  - Injections, Intramuscular
MH  - Telemetry/veterinary
MH  - Xylazine/administration & dosage/*pharmacology
EDAT- 2004/05/26 05:00
MHDA- 2004/06/16 05:00
CRDT- 2004/05/26 05:00
PHST- 2004/05/26 05:00 [pubmed]
PHST- 2004/06/16 05:00 [medline]
PHST- 2004/05/26 05:00 [entrez]
AID - 10.1111/j.1439-0442.2004.00585.x [doi]
PST - ppublish
SO  - J Vet Med A Physiol Pathol Clin Med. 2003 Dec;50(10):479-83. doi: 
      10.1111/j.1439-0442.2004.00585.x.