PMID- 15157829
OWN - NLM
STAT- MEDLINE
DCOM- 20041019
LR  - 20101118
IS  - 1521-6918 (Print)
IS  - 1521-6918 (Linking)
VI  - 18
IP  - 3
DP  - 2004 Jun
TI  - The contribution of HLA genes to IBD susceptibility and phenotype.
PG  - 577-96
AB  - The human leukocyte antigen (HLA) region located on chromosome 6p encodes the 
      highly polymorphic, classical class I and II genes essential for normal 
      lymphocyte function; it also encodes a further 224 genes. Many early studies 
      investigating this region were limited by small sample size, poor statistical 
      methodology, population stratification and variable disease definition. Although 
      more recent studies have improved study design, investigators are still 
      challenged by the complex patterns of linkage disequilibrium across this 
      gene-dense region, and by the disease heterogeneity characteristic of all 
      genetically complex disorders. However, a number of important observations have 
      emerged from recent studies: (1) the HLA harbours gene(s) that determine 
      susceptibility to colonic inflammation in both ulcerative colitis (UC) and 
      Crohn's disease (CD); (2) most of the specific associations with UC and CD appear 
      to differ; (3) associations between different ethnic groups differ; (4) markers 
      in the HLA might predict the course of disease and the development of 
      complications, notably the extraintestinal manifestations of disease.
FAU - Yap, Lee Min
AU  - Yap LM
AD  - Gastroenterology Unit, Gibson Laboratories, University of Oxford, Radcliffe 
      Infirmary, Woodstock Road, Oxford OX2 6HE, UK. yaplm@well.ox.ac.uk
FAU - Ahmad, Tariq
AU  - Ahmad T
FAU - Jewell, Derek P
AU  - Jewell DP
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - Best Pract Res Clin Gastroenterol
JT  - Best practice & research. Clinical gastroenterology
JID - 101120605
RN  - 0 (HLA Antigens)
RN  - 0 (Heat-Shock Proteins)
RN  - 0 (Lymphotoxin-alpha)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Colitis, Ulcerative/*genetics
MH  - Crohn Disease/*genetics
MH  - Genetic Linkage
MH  - Genetic Predisposition to Disease
MH  - HLA Antigens/*genetics
MH  - Heat-Shock Proteins/genetics
MH  - Humans
MH  - Lymphotoxin-alpha/genetics
MH  - Major Histocompatibility Complex/*genetics
MH  - Phenotype
MH  - Tumor Necrosis Factor-alpha/genetics
RF  - 110
EDAT- 2004/05/26 05:00
MHDA- 2004/10/20 09:00
CRDT- 2004/05/26 05:00
PHST- 2004/05/26 05:00 [pubmed]
PHST- 2004/10/20 09:00 [medline]
PHST- 2004/05/26 05:00 [entrez]
AID - S1521691804000113 [pii]
AID - 10.1016/j.bpg.2004.01.003 [doi]
PST - ppublish
SO  - Best Pract Res Clin Gastroenterol. 2004 Jun;18(3):577-96. doi: 
      10.1016/j.bpg.2004.01.003.