PMID- 15161052
OWN - NLM
STAT- MEDLINE
DCOM- 20040719
LR  - 20041117
IS  - 0250-7005 (Print)
IS  - 0250-7005 (Linking)
VI  - 24
IP  - 2B
DP  - 2004 Mar-Apr
TI  - Comparison of surface HLA class I levels in squamous cell carcinoma cell lines of 
      the head and neck.
PG  - 973-9
AB  - BACKGROUND: Squamous cell carcinomas of the head and neck (SCCHN) are the most 
      frequent malignancies in this region. Down-regulation of human leukocyte antigen 
      (HLA) class I was found to be implicated in the immune escape of these tumors. 
      MATERIALS AND METHODS: Cell surface expression levels of several HLA class I 
      antigens were evaluated in 21 SCCHN cell lines utilizing FACS analysis. RESULTS: 
      Expression levels of HLA-antigens varied significantly between the investigated 
      cell lines. On average higher HLA-B27 expression levels were observed in cell 
      lines from younger and female patients. CONCLUSION: Our data confirms 
      down-regulation of HLA class I to be an important event in SCCHN. However, since 
      several SCCHN cell lines also exhibited high HLA levels, other mechanisms than 
      HLA down-regulation also need to be considered as a cause for disease 
      progression. Further studies will be required to elucidate the potential role of 
      HLA-B27 in SCCHN.
FAU - Mandic, Robert
AU  - Mandic R
AD  - Department of Otolaryngology, Head and Neck Surgery, Philipps University Marburg, 
      Deutschhausstrasse 3, D-35037 Marburg, Germany. mandic@mailer.uni-marburg.de
FAU - Lieder, Anja
AU  - Lieder A
FAU - Sadowski, Maria
AU  - Sadowski M
FAU - Peldszus, Roswitha
AU  - Peldszus R
FAU - Werner, Jochen A
AU  - Werner JA
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
RN  - 0 (Antigens, Surface)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B27 Antigen)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Antigens, Surface/biosynthesis
MH  - Carcinoma, Squamous Cell/*immunology
MH  - Cell Line, Tumor
MH  - Down-Regulation
MH  - Female
MH  - Flow Cytometry
MH  - HLA-A Antigens/*biosynthesis
MH  - HLA-B27 Antigen/*biosynthesis
MH  - Head and Neck Neoplasms/*immunology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Sex Factors
EDAT- 2004/05/27 05:00
MHDA- 2004/07/20 05:00
CRDT- 2004/05/27 05:00
PHST- 2004/05/27 05:00 [pubmed]
PHST- 2004/07/20 05:00 [medline]
PHST- 2004/05/27 05:00 [entrez]
PST - ppublish
SO  - Anticancer Res. 2004 Mar-Apr;24(2B):973-9.