PMID- 15161710
OWN - NLM
STAT- MEDLINE
DCOM- 20041210
LR  - 20081121
IS  - 1078-0432 (Print)
IS  - 1078-0432 (Linking)
VI  - 10
IP  - 10
DP  - 2004 May 15
TI  - The 5A/6A polymorphism of the matrix metalloproteinase 3 gene promoter and breast 
      cancer.
PG  - 3518-20
AB  - PURPOSE: The matrix metalloproteinase 3 (MMP3), also known as stromelysin-I, is a 
      key-player for carcinogenesis and tumor growth. A 5A/6A promoter polymorphism is 
      associated with differences in MMP3 activity and has been linked to cancer 
      susceptibility in some studies. In the present study we evaluated the role of 
      this polymorphism for breast cancer risk. EXPERIMENTAL DESIGN: A case-control 
      study was performed including 500 patients with histologically confirmed breast 
      cancer and 500 female, age-matched, healthy control subjects from 
      population-based screening studies. The MMP3 5A/6A polymorphism was determined by 
      a 5'-nuclease (TaqMan) assay. RESULTS: Prevalences of 5A/5A, 5A/6A, and 6A/6A 
      genotypes were similar among patients (20.6, 51.8, and 27.6%, respectively) and 
      controls (23.3, 47.3, and 29.4%, P = 0.34). The odds ratio of carriers of a MMP3 
      5A allele for breast cancer was 1.09 (95% confidence interval, 0.83-1.44). 
      Patients with the 5A/5A genotype had a higher proportion of lymph-node metastases 
      than those with a 5A/6A or 6A/6A genotype (P = 0.010). CONCLUSIONS: The MMP3 
      5A/6A promoter polymorphism does not appear to influence breast cancer 
      susceptibility but may be linked to a higher risk for metastasizing among breast 
      cancer patients.
FAU - Krippl, Peter
AU  - Krippl P
AD  - Department of Internal Medicine, Division of Oncology, Medical University Graz, 
      Graz, Austria. peter.krippl@klinikum-graz.at
FAU - Langsenlehner, Uwe
AU  - Langsenlehner U
FAU - Renner, Wilfried
AU  - Renner W
FAU - Yazdani-Biuki, Babak
AU  - Yazdani-Biuki B
FAU - Koppel, Herwig
AU  - Koppel H
FAU - Leithner, Andreas
AU  - Leithner A
FAU - Wascher, Thomas C
AU  - Wascher TC
FAU - Paulweber, Bernhard
AU  - Paulweber B
FAU - Samonigg, Hellmut
AU  - Samonigg H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Clin Cancer Res
JT  - Clinical cancer research : an official journal of the American Association for 
      Cancer Research
JID - 9502500
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alleles
MH  - Breast Neoplasms/*genetics
MH  - Case-Control Studies
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Lymphatic Metastasis
MH  - Matrix Metalloproteinase 3/*genetics
MH  - Middle Aged
MH  - Models, Genetic
MH  - Odds Ratio
MH  - *Polymorphism, Genetic
MH  - *Promoter Regions, Genetic
EDAT- 2004/05/27 05:00
MHDA- 2004/12/16 09:00
CRDT- 2004/05/27 05:00
PHST- 2004/05/27 05:00 [pubmed]
PHST- 2004/12/16 09:00 [medline]
PHST- 2004/05/27 05:00 [entrez]
AID - 10/10/3518 [pii]
AID - 10.1158/1078-0432.CCR-04-0010 [doi]
PST - ppublish
SO  - Clin Cancer Res. 2004 May 15;10(10):3518-20. doi: 10.1158/1078-0432.CCR-04-0010.