PMID- 15162044
OWN - NLM
STAT- MEDLINE
DCOM- 20041101
LR  - 20131121
IS  - 1424-859X (Electronic)
IS  - 1424-8581 (Linking)
VI  - 104
IP  - 1-4
DP  - 2004
TI  - Cytogenetic analyses in peripheral lymphocytes of persons living in houses with 
      increased levels of indoor radon concentrations.
PG  - 232-6
AB  - Published data concerning the effects of indoor radon exposure on the frequency 
      of chromosome aberrations in peripheral lymphocytes of residents are 
      contradictory. Possible reasons for this may be the low radon concentration in 
      dwellings and/or the limited number of investigated persons. We therefore studied 
      the relationship of domestic radon exposure and the occurrence of chromosome 
      aberrations in peripheral lymphocytes in 61 persons living in houses with radon 
      concentrations from 80 up to 13,000 Bq/m3. We analyzed 60,000 cells from 
      fluorescence plus Giemsa (FPG)-stained slides. It could be clearly demonstrated 
      that in groups of persons living in dwellings with indoor radon concentrations 
      >200 Bq/m3 the number of cells containing dicentrics and/or centric rings (C(dic 
      + cr)) (2.45 +/- 0.50 x 10(-3)) was significantly increased (p < 0.05) in 
      comparison to the control level (1.03 +/- 0.15 x 10(-3)). However, there was no 
      difference in the mean frequency of C(dic + cr) between the groups living in 
      dwellings with higher radon concentrations. Using the fluorescence in situ 
      hybridization (FISH) technique for the detection of translocations, we analyzed 
      23,315 cells in 16 persons of the highest exposed group (>5,000 Bq/m3). The 
      observed frequency of translocations was 3.9 +/- 0.64 x 10(-3). In comparison to 
      the control group (2.02 +/- 0.18 x 10(-3)), there was a slight but not 
      statistically significant increase in the exposed group (P = 0.055). If, however, 
      the age of the examined persons is taken into account, the values are 
      significantly increased (P < 0.05) in the exposed persons older than 40 years in 
      comparison to the age-matched controls. Since most of the translocations were 
      found in stable cells, it is concluded that translocations are also induced in 
      blood-forming tissue and are transmitted to peripheral blood.
CI  - Copyright 2003 S. Karger AG, Basel
FAU - Oestreicher, U
AU  - Oestreicher U
AD  - Federal Office for Radiation Protection, Department of Radiation Protection and 
      Health, Oberschleissheim, Germany. uoestreicher@bfs.de
FAU - Braselmann, H
AU  - Braselmann H
FAU - Stephan, G
AU  - Stephan G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Cytogenet Genome Res
JT  - Cytogenetic and genome research
JID - 101142708
RN  - Q74S4N8N1G (Radon)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Bone Marrow/radiation effects
MH  - Cells, Cultured/radiation effects/ultrastructure
MH  - Child
MH  - *Chromosome Aberrations
MH  - Female
MH  - Hematopoiesis/radiation effects
MH  - *Housing
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Lymphocytes/*radiation effects/ultrastructure
MH  - Male
MH  - Middle Aged
MH  - Radon/*adverse effects
MH  - Smoking
MH  - Translocation, Genetic
EDAT- 2004/05/27 05:00
MHDA- 2004/11/02 09:00
CRDT- 2004/05/27 05:00
PHST- 2003/09/10 00:00 [received]
PHST- 2003/12/10 00:00 [accepted]
PHST- 2004/05/27 05:00 [pubmed]
PHST- 2004/11/02 09:00 [medline]
PHST- 2004/05/27 05:00 [entrez]
AID - 77495 [pii]
AID - 10.1159/000077495 [doi]
PST - ppublish
SO  - Cytogenet Genome Res. 2004;104(1-4):232-6. doi: 10.1159/000077495.