PMID- 15162399
OWN - NLM
STAT- MEDLINE
DCOM- 20041203
LR  - 20131121
IS  - 0233-111X (Print)
IS  - 0233-111X (Linking)
VI  - 44
IP  - 3
DP  - 2004
TI  - Control of pyrimidine biosynthesis in "Pseudomonas alkanolytica" ATCC 21034.
PG  - 253-7
AB  - The control of de novo pyrimidine biosynthesis in the industrially important 
      patent strain "Pseudomonas alkanolytica" ATCC 21034 was investigated. Uracil 
      supplementation of succinate-grown "P. alkanolytica" cells produced the greatest 
      depression of the de novo pyrimidine biosynthetic pathway enzyme activities. 
      After the pyrimidine limitation of a "P. alkanolytica" orotate 
      phosphoribosyltransferase mutant strain grown on succinate, the pyrimidine 
      biosynthetic pathway enzyme activities were derepressed. The pyrimidine 
      biosynthetic pathway enzyme aspartate transcarbamoylase in "P. alkanolytica" was 
      inhibited by pyrophosphate, cytidine 5'-triphosphate (CTP), uridine 
      5'-triphosphate (UTP), and guanosine 5'-triphosphate (GTP).
CI  - Copyright 2004 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
FAU - West, Thomas P
AU  - West TP
AD  - Olson Biochemistry Laboratories, Department of Chemistry and Biochemistry, South 
      Dakota State University, Brookings, SD 57007, USA. Thomas_West@sdstate.edu
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - J Basic Microbiol
JT  - Journal of basic microbiology
JID - 8503885
RN  - 0 (Diphosphates)
RN  - 0 (Pyrimidines)
RN  - 56HH86ZVCT (Uracil)
RN  - 65-47-4 (Cytidine Triphosphate)
RN  - 86-01-1 (Guanosine Triphosphate)
RN  - AB6MNQ6J6L (Succinic Acid)
RN  - EC 2.1.3.2 (Aspartate Carbamoyltransferase)
RN  - EC 2.4.2.10 (Orotate Phosphoribosyltransferase)
RN  - K8CXK5Q32L (pyrimidine)
RN  - UT0S826Z60 (Uridine Triphosphate)
SB  - IM
MH  - Aspartate Carbamoyltransferase/metabolism
MH  - Cytidine Triphosphate/metabolism
MH  - Diphosphates/metabolism
MH  - Enzyme Repression
MH  - *Gene Expression Regulation, Bacterial
MH  - Genes, Bacterial
MH  - Guanosine Triphosphate/metabolism
MH  - Mutation
MH  - Orotate Phosphoribosyltransferase/genetics/metabolism
MH  - Pseudomonas/enzymology/genetics/*metabolism
MH  - Pyrimidines/*biosynthesis
MH  - Succinic Acid/metabolism
MH  - Uracil/metabolism
MH  - Uridine Triphosphate/metabolism
EDAT- 2004/05/27 05:00
MHDA- 2004/12/16 09:00
CRDT- 2004/05/27 05:00
PHST- 2004/05/27 05:00 [pubmed]
PHST- 2004/12/16 09:00 [medline]
PHST- 2004/05/27 05:00 [entrez]
AID - 10.1002/jobm.200310373 [doi]
PST - ppublish
SO  - J Basic Microbiol. 2004;44(3):253-7. doi: 10.1002/jobm.200310373.