PMID- 15162825
OWN - NLM
STAT- MEDLINE
DCOM- 20041007
LR  - 20191210
IS  - 1341-9625 (Print)
IS  - 1341-9625 (Linking)
VI  - 9
IP  - 1
DP  - 2004 Feb
TI  - Impact of serum interleukin-18 level as a prognostic indicator in patients with 
      epithelial ovarian carcinoma.
PG  - 42-6
AB  - BACKGROUND: Interleukin-18 (IL-18), a cytokine produced by macrophages, is 
      capable of inducing T-lymphocyte synthesis of interferon-gamma (IFN-gamma). In 
      this study, for the first time, the serum concentration of IL-18 and its 
      significance as a prognostic indicator was evaluated in patients with epithelial 
      ovarian cancer. METHODS: The serum IL-18 level was measured by an enzyme-linked 
      immunosorbent assay (ELISA) in 69 patients with epithelial ovarian cancer and 8 
      healthy controls. Relationships between the IL-18 level and clinicopathological 
      features were examined by univariate and multivariate analyses. RESULTS: The 
      median serum IL-18 level in the ovarian cancer patients was 229.6 pg/ml, and the 
      level was significantly elevated compared with that in the normal controls (151.3 
      pg/ml; P < 0.01). No significant correlations were detected between the IL-18 
      level and stage or histology (P = 0.08 and P = 0.12, respectively). On univariate 
      analysis, overall survival was shown to be affected by IL-18 serum levels. 
      However, multivariate analysis failed to demonstrate an independent prognostic 
      significance for IL-18 serum levels, while confirming the role of previously 
      established prognostic variables, such as performance status, stage, and residual 
      tumor. CONCLUSION: This study showed that IL-18 serum levels were elevated in 
      ovarian cancer patients and were correlated with overall survival, although they 
      were shown not to be an independent prognostic factor.
FAU - Akahiro, Jun-ichi
AU  - Akahiro J
AD  - Department of Obstetrics and Gynecology, Tohoku University Graduate School of 
      Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan. 
      jakahira-tohoku@umin.ac.jp
FAU - Konno, Ryo
AU  - Konno R
FAU - Ito, Kiyoshi
AU  - Ito K
FAU - Okamura, Kunihiro
AU  - Okamura K
FAU - Yaegashi, Nobuo
AU  - Yaegashi N
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Int J Clin Oncol
JT  - International journal of clinical oncology
JID - 9616295
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Adult
MH  - Biomarkers, Tumor/blood
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Interleukin-18/*blood
MH  - Japan
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Neoplasm Staging
MH  - Neoplasms, Glandular and Epithelial/*blood/*diagnosis/mortality
MH  - Ovarian Neoplasms/*blood/*diagnosis/mortality
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Statistics as Topic
MH  - Survival Analysis
MH  - Women's Health
EDAT- 2004/05/28 05:00
MHDA- 2004/10/08 09:00
CRDT- 2004/05/28 05:00
PHST- 2004/05/28 05:00 [pubmed]
PHST- 2004/10/08 09:00 [medline]
PHST- 2004/05/28 05:00 [entrez]
AID - 10.1007/s10147-003-0360-6 [doi]
PST - ppublish
SO  - Int J Clin Oncol. 2004 Feb;9(1):42-6. doi: 10.1007/s10147-003-0360-6.