PMID- 15165177
OWN - NLM
STAT- MEDLINE
DCOM- 20040803
LR  - 20081121
IS  - 1462-2416 (Print)
IS  - 1462-2416 (Linking)
VI  - 5
IP  - 4
DP  - 2004 Jun
TI  - Variation in vaccine response in normal populations.
PG  - 417-27
AB  - Genetic polymorphisms of the human leukocyte antigen (HLA) system significantly 
      influence the variation in immune responses to viral vaccines. Considerable data 
      on the genetic determinants of immune responses to the measles vaccine support 
      the importance of HLA genes in determining the variation in vaccine response. HLA 
      class I and class II, TAP, and HLA-DM allele associations with measles-specific 
      antibody levels following measles vaccination have revealed, in part, the 
      immunologic basis for mechanisms of measles immunity variation. Associations 
      between HLA genotype and immune responses have also been reported for other 
      vaccines and infectious diseases, such as hepatitis B and C, human 
      papillomaviruses, and influenza. Vaccine pharmacogenomics may provide important 
      insights for the design and development of new peptide-based vaccines against 
      measles and other pathogens.
FAU - Ovsyannikova, Inna G
AU  - Ovsyannikova IG
AD  - Mayo Vaccine Research Group, 611C Guggenheim Building, Mayo Clinic, 200 First 
      Street SW, Rochester, Minnesota 55905, USA.
FAU - Jacobson, Robert M
AU  - Jacobson RM
FAU - Poland, Gregory A
AU  - Poland GA
LA  - eng
GR  - AI 33144/AI/NIAID NIH HHS/United States
GR  - AI 48793/AI/NIAID NIH HHS/United States
GR  - AI 53592/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - England
TA  - Pharmacogenomics
JT  - Pharmacogenomics
JID - 100897350
RN  - 0 (Vaccines)
SB  - IM
MH  - Genetic Variation/*genetics/immunology
MH  - Humans
MH  - Normal Distribution
MH  - Polymorphism, Genetic/*genetics/immunology
MH  - Vaccination/statistics & numerical data
MH  - Vaccines/*administration & dosage/*immunology
RF  - 102
EDAT- 2004/05/29 05:00
MHDA- 2004/08/04 05:00
CRDT- 2004/05/29 05:00
PHST- 2004/05/29 05:00 [pubmed]
PHST- 2004/08/04 05:00 [medline]
PHST- 2004/05/29 05:00 [entrez]
AID - PGS050409 [pii]
AID - 10.1517/14622416.5.4.417 [doi]
PST - ppublish
SO  - Pharmacogenomics. 2004 Jun;5(4):417-27. doi: 10.1517/14622416.5.4.417.